28354-24-7

Basic information

• Product Name: N-(2,4-dimethyl-phenyl)-glycine nitrile
• Synonyms: N-(2,4-dimethyl-phenyl)-glycine nitrile
• CAS NO: 28354-24-7
• Molecular Weight: 160.219
• Mol File: 28354-24-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2,4-dimethyl-phenyl)-glycine nitrile(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-dimethyl-phenyl)-glycine nitrile(28354-24-7)
• EPA Substance Registry System: N-(2,4-dimethyl-phenyl)-glycine nitrile(28354-24-7)

Safety Data

• Hazardous Substances Data: 28354-24-7(Hazardous Substances Data)

Upstream product

• 151-50-8 potassium cyanide 
• 95-68-1 2,4-Xylidine 
• 7677-24-9 trimethylsilyl cyanide 
• 60397-77-5 N-(2,4-dimethylphenyl)formamide 

Relevant articles and documents

Iron-catalyzed reductive strecker reaction

Strecker reaction is widely applied for the synthesis of amino acids from aldehydes, amines and cyanides. Herein, we report the FeI2-catalyzed reductive Strecker type reaction of formamides instead of aldehydes to produce amino acetonitriles. The challenging capture of carbinolamine intermediates by CN? was achieved via Fe catalysis. This approach afforded better yields than the use of Ir- or Rh-catalysts. The application ability of this methodology is demonstrated by 1) one-pot construction of (13C labeled) complex molecules from CO2 via amino acetonitrile intermediates and 2) convenient production of homologated carboxylic acids from aldehydes.