28392-96-3

Basic information

• Product Name: 3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin
• Synonyms: 3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin;4-Hydroxy-3-(3-hydroxy-1-phenylbutyl)-2H-1-benzopyran-2-one;4-Hydroxy-3-[α-(2-hydroxypropyl)benzyl]couMarin;Warfarin Alcohol (Mixture of DiastereoMers)
• CAS NO: 28392-96-3
• Molecular Formula: C₁₉H₁₈O₄
• Molecular Weight: 310.34382
• Mol File: 28392-96-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 494.6°Cat760mmHg
• Flash Point: 179.3°C
• Appearance: /
• Density: 1.312g/cm³
• Vapor Pressure: 1.33E-10mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin(28392-96-3)
• EPA Substance Registry System: 3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin(28392-96-3)

Safety Data

• Hazardous Substances Data: 28392-96-3(Hazardous Substances Data)

Usage

Uses

Warfarin Alcohol is the hydroxy analogue of Warfarin with anticoagulant activity.

InChI:InChI=1/C19H18O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,12,15,20,22H,11H2,1H3

Upstream product

• 81-81-2 warfarin 

Relevant articles and documents

Anti-warfarin antibody preparation and its characterization for radioimmunoassay

Anti-warfarin antiserum was prepared in rabbits by immunization with a synthesized warfarin antigen, 4'-azo-warfarin human serum albumin, which possesses two enantiomorphic haptenic sites of warfarin on the molecule. The antiserum recognized both R- and S-warfarin to the same degree, 50% cross reactivities of racemic warfarin, respectively. One of the warfarin metabolites, racemic warfarin alcohol, showed 1% cross reactivity, and R- or S-warfarin alcohol have half the reactivity of the racemic alcohol. Rabbit plasma warfarin levels were determined by radioimmunoassay using this antiserum and racemic [14C]warfarin and by fluorometric assay after isolation by thin layer chromatography. After a single administration of warfarin (2 mg kg-1 orally or 400 μg kg-1 i.v.), the plasma levels determined by both assay methods showed a good correlation (r = 0.97, P 0.001, Y = 1.04-0.09). The results show that the radioimmunoassay can determine total plasma warfarin without interference of plasma metabolite. The applicability and limitation of the radioimmunoassay for pharmacokinetic study are discussed.

4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL[B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS

The present invention relates to compounds of formula I which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl[b]pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. STR1 Wherein R 10 and R 20 taken together are: STR2