2840-10-0Relevant articles and documents
Stereoselectivity in the formation of tris-diimine complexes of Fe(ii), Ru(ii), and Os(ii) with a C2-symmetric chiral derivative of 2,2′-bipyridine
Drahonovsky, Dusan,Knof, Ulrich,Jungo, Laurence,Belser, Thomas,Neels, Antonia,Labat, Gael Charles,Stoeckli-Evans, Helen,Von Zelewsky, Alex
, p. 1444 - 1454 (2006)
A C2-symmetric enantiopure 4,5-bis(pinene)-2, 2′-bipyridine ligand (-)-L was used to investigate the diastereoselectivity in the formation of [ML3]2+ coordination species (M = Fe(ii), Ru(ii), Os(ii), Zn(ii), Cd(ii), Cu(ii), Ni(ii)), and [ML2Cl2] (M = Ru(ii), Os(ii)). The X-ray structures of the [ML3]2+ complexes were determined for Δ-[FeL3](PF6)2, Δ-[RuL 3](PF6)2, Λ-[RuL3](PF 6)2, Δ-[OsL3](PF6) 2, and Λ-[OsL3](TfO)2. All of these compounds were also characterized by NMR, CD and UV/VIS absorption spectroscopy. The [FeL3]2+ diastereoisomers were studied in equilibrated solutions at various temperatures and in several solvents. The [RuL3]2+ complexes, which are thermally stable up to 200 °C, were photochemically equilibrated. The Royal Society of Chemistry 2006.
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d] pyrimidin-4-ylamine: Structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors
Matulenko, Mark A.,Lee, Chih-Hung,Jiang, Meiqun,Frey, Robin R.,Cowart, Marlon D.,Bayburt, Erol K.,DiDomenico Jr., Stanley,Gfesser, Gregory A.,Gomtsyan, Arthur,Guo, Zhu Zheng,McKie, Jeffery A.,Stewart, Andrew O.,Yu, Haixia,Kohlhaas, Kathy L.,Alexander, Karen M.,McGaraughty, Steve,Wismer, Carol T.,Mikusa, Joseph,Marsh, Kennan C.,Snyder, Ronald D.,Diehl, Marilyn S.,Kowaluk, Elizabeth A.,Jarvis, Michael F.,Bhagwat, Shripad S.
, p. 3705 - 3720 (2007/10/03)
4-Amino-5,7-disubstituted pyridopyrimidines are potent, non-nucleoside inhibitors of adenosine kinase (AK). We recently identified a potent, orally efficacious analog, 4 containing a 7-pyridylmorpholine substituted ring system as the key structural element of this template. In this report, we disclose the pharmacologic effects of five- and six-membered heterocyclic ring replacements for the pyridine ring in 4. These replacements were found to have interesting effects on in vivo efficacy and genotoxicity as well as in vitro potency. We discovered that the nitrogen in the heterocyclic ring at C(7) is important for the modulation of mutagenic side effects (Ames assay).
Kinetics of the Enolisation Reactions of 2-Acetylpyrrole and of 2-, 4- and 5-Acetylthiazoles
Maria, Paolo De,Fontana, Antonella,Arlotta, Marialuisa,Chimichi, Stefano,Spinelli, Domenico
, p. 415 - 420 (2007/10/02)
Kinetic results are reported on the rates of enolisation of title compounds in water, in acetate buffers, in dilute hydrochloric acid, in dilute sodium hydroxide solutions and in the presence of several metal-ion salts, as measured by their rates of halogenation at 25 deg C.The results have been compared with those previously obtained from the corresponding reactions of acetophenone and a number of acetylheterocycles.It is shown that a suitable metal cation (e.g., Cu2+) can be hundreds of times more effective than the proton in catalysing the enolisation process of an acetylheterocyclic compound.This can be due either to the 'soft' character of the acetyl group, as, for example, that of 2-acetylpyrrole, or to coordination of both the carbonyl oxygen and the heteroatom by the metal cation in the transition state of the reaction, as for 2- and 4-acetylthiazoles.
