2848-01-3 Usage
Description
3-(Diphenylphosphino)propionic acid is an organic compound that features a diphenylphosphino group attached to a propionic acid backbone. This molecule is known for its unique chemical properties, which make it a versatile reagent in various chemical reactions and applications.
Uses
Used in Organocatalysis:
3-(Diphenylphosphino)propionic acid is used as a catalyst in organocatalytic asymmetric aziridination of imines and diazo compounds. Its phosphino group facilitates the selective formation of chiral aziridines, which are important building blocks in the synthesis of biologically active molecules and pharmaceuticals.
Used in Phosphine-mediated Conversions:
In the chemical industry, 3-(Diphenylphosphino)propionic acid serves as a reagent for the conversion of azides into diazo compounds. This transformation is crucial for the synthesis of various organic molecules and materials, as diazo compounds are key intermediates in numerous chemical reactions.
Used in the Preparation of Rhodium Catalysts:
3-(Diphenylphosphino)propionic acid is utilized in the preparation of rhodium catalysts for hydroformylation, a critical industrial process for converting alkenes into aldehydes. The phosphino group in the molecule enhances the catalytic activity and selectivity of the rhodium catalysts, making it an essential component in this application.
Used in the Synthesis of Mitsunobu Reagents:
3-(Diphenylphosphino)propionic acid is also employed in the synthesis of reagents for the Mitsunobu reaction, a widely used method for the inversion of stereochemistry and the formation of new carbon-heteroatom bonds. The diphenylphosphino group in 3-(Diphenylphosphino)propionic acid contributes to the efficiency and selectivity of the Mitsunobu reagents, making it a valuable component in this reaction.
Check Digit Verification of cas no
The CAS Registry Mumber 2848-01-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,4 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2848-01:
(6*2)+(5*8)+(4*4)+(3*8)+(2*0)+(1*1)=93
93 % 10 = 3
So 2848-01-3 is a valid CAS Registry Number.
2848-01-3Relevant articles and documents
A Palladium-Free Sonogashira Coupling Protocol Employing an in Situ Prepared Copper/Chelating 1,2,3-Triazolylidene System
Tonis, Efstathios,Stein, Felix,Stamatopoulos, Ioannis K.,Stubbe, Jessica,Zarkadoulas, Athanasios,Sarkar, Biprajit,Vougioukalakis, Georgios C.
, p. 616 - 620 (2020/11/25)
A new, palladium-free Sonogashira coupling reaction protocol using a catalytic system that comprises a simple, cheap, widely available copper salt and a chelating 1,2,3-triazolylidene ligand precursor is reported. This protocol provides the desired coupling products in moderate to very good yields.
Cyclic decapeptide gramicidin S derivatives containing phosphines: Novel ligands for asymmetric catalysis
Guisado-Barrios, Gregorio,Mu?oz, Bianca K.,Kamer, Paul C. J.,Lastdrager, Bas,Van Der Marel, Gijs,Overhand, Mark,Vega-Vázquez, Marino,Martin-Pastor, Manuel
supporting information, p. 1973 - 1978 (2013/05/22)
The cyclic peptide gramicidin S was used as a rigid template to provide novel peptide-based bisphosphine ligands for transition metal catalysis. Two bisphosphine-coordinated Rh(i) complexes allowed asymmetric hydrogenation with 10-52% ee and the corresponding Pd(ii) analogues catalysed asymmetric allylic alkylation with 13-15% ee. The Royal Society of Chemistry 2013.
A Phosphine-mediated conversion of azides into diazo compounds
Myers, Eddie L.,Raines, Ronald T.
supporting information; experimental part, p. 2359 - 2363 (2009/09/24)
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