28547-33-3

Basic information

• Product Name: 1-(4-T-BUTYLPHENYL)-3-CHLOROPROPAN-1-ONE
• Synonyms: 1-(4-T-BUTYLPHENYL)-3-CHLOROPROPAN-1-ONE;1-(4-tert-butylphenyl)-3-chloropropan-1-one
• CAS NO: 28547-33-3
• Molecular Formula: C₁₃H₁₇ClO
• Molecular Weight: 224.73
• Mol File: 28547-33-3.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-T-BUTYLPHENYL)-3-CHLOROPROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-T-BUTYLPHENYL)-3-CHLOROPROPAN-1-ONE(28547-33-3)
• EPA Substance Registry System: 1-(4-T-BUTYLPHENYL)-3-CHLOROPROPAN-1-ONE(28547-33-3)

Safety Data

• Hazardous Substances Data: 28547-33-3(Hazardous Substances Data)

Usage

Description

1-(4-T-BUTYLPHENYL)-3-CHLOROPROPAN-1-ONE, with the molecular formula C13H17ClO, is a ketone that features a t-butylphenyl group and a chlorine atom attached to a three-carbon chain. This chemical compound is known for its versatile reactivity and functional groups, making it a valuable component in the synthesis of various pharmaceuticals and organic compounds.

Uses

Used in Pharmaceutical Synthesis:
1-(4-T-BUTYLPHENYL)-3-CHLOROPROPAN-1-ONE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to react with a range of other compounds, contributing to the development of new medications.
Used in Organic Chemistry:
In the field of organic chemistry, 1-(4-T-BUTYLPHENYL)-3-CHLOROPROPAN-1-ONE serves as a reagent or intermediate in the production of complex molecules, facilitating the creation of advanced organic compounds.
Used in Chemical Research:
1-(4-T-BUTYLPHENYL)-3-CHLOROPROPAN-1-ONE may also be utilized in chemical research to explore its properties and potential applications, further expanding the understanding of its role in chemical reactions and synthesis processes.
It is crucial to handle 1-(4-T-BUTYLPHENYL)-3-CHLOROPROPAN-1-ONE with care due to its potential hazards as a chemical reagent, ensuring safety in its applications across various industries.

Upstream product

• 253185-03-4 tert-butylbenzene 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 4600-86-6 5-(tert-butyl)-2,3-dihydro-1H-inden-1-one 
• 4600-87-7 5-tert.-Butyl-2-(4-dimethylamino-benzyliden)-indanon-⁽¹⁾ 
• 1353347-96-2 3-(4-(tert-butyl)phenyl)-4,5-dihydrofuran-2-carbaldehyde 
• 1353347-94-0 4-(4-(tert-butyl)phenyl)-5,6-dihydro-2H-pyran-2-one 
• 1353347-80-4 2-(4-(tert-butyl)phenyl)-2-ethynyloxetane 
• 935680-90-3 5-tert-butyl-2,3-dihydro-1H-inden-1-ylamine 
• 808756-83-4 (1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-ylamine 
• 934593-36-9 (1R)-5-tert-butyl-indan-1-ylamine tosylate 
• 808756-71-0 N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea 
• 28547-36-6 3-chloro-1-(4-tert-butylphenyl)-1-propanol 
• 1178884-68-8 6-(tert-butyl)-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

Preparation, physical properties and n-type FET characteristics of substituted diindenopyrazinediones and bis(dicyanomethylene) derivatives

A series of halogen and alkyl substituted diindenopyrazinediones and bis(dicyanomethylene) derivatives have been synthesized as new n-type organic semiconductors based on nitrogen-containing heterocycles. Halogen groups were introduced to improve the electron injection. Their crystal structures and solid physical properties are discussed. Alkyl groups were introduced to increase the solubility in organic solvents. Furthermore, hexanoyl groups were introduced by oxidation of alkyl groups to increase the solubility and electron affinity. Dicyanomethylene groups were also introduced to further enhance the electron-accepting properties. Drop-cast as well as vapour deposited thin films showed n-type FET properties.

Synthesis and Evaluation of 2-Azetidinone and 1H-Pyrrole-2,5-dione Derivatives as Cholesterol Absorption Inhibitors for Reducing Inflammation Response and Oxidative Stress

Excess lipid accumulation can initiate the development and progression of atherosclerotic lesions, thus eventually leading to cardiovascular disease. Lipid-lowering medication therapy is one of the cornerstones of cardiovascular disease therapy. On the basis of the cholesterol absorption inhibitor ezetimibe, we successfully synthesized seven 2-azetidinone derivatives and eighteen 1H-pyrrole-2,5-dione derivatives. Most of the new compounds significantly inhibited cholesterol uptake in vitro. In addition, one of the most active inhibitors, 3-(4-fluorophenyl)-1-[(3S)-3-hydroxy-3-(4-hydroxyphenyl)propyl]-4-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione (14q), showed no cytotoxicity in L02 and HEK293T cell lines. Further evaluation indicated that 14q inhibited considerably the amount of TNF-α, ROS, MDA, and LDH in vitro. Therefore, 14q might be a novel cholesterol absorption inhibitor.

A combined computational and experimental investigation of the oxidative ring-opening of cyclic ethers by oxoammonium cations

The propensity of oxoammonium cations to facilitate the oxidative ring-opening of cyclic ethers to their corresponding distal hydroxy ketones is investigated. The reaction has been evaluated using experimental and computational methods to gain deeper insight into trends in reactivity.