28614-26-8 Usage
Description
N-METHYLQUIPAZINE DIMALEATE, also known as a maleate salt, is a compound derived from the reaction of N-methylquipazine with two equivalents of maleic acid. It is a 5-HT3 agonist, which means it has the ability to bind to and activate the 5-HT3 receptor. N-METHYLQUIPAZINE DIMALEATE has almost the same affinity for 5-HT3 sites as quipazine, but unlike quipazine, it does not bind to 5-HT1B sites.
Uses
Used in Pharmaceutical Industry:
N-METHYLQUIPAZINE DIMALEATE is used as a 5-HT3 agonist for its ability to activate the 5-HT3 receptor. This makes it a potential candidate for the development of medications targeting various conditions related to the serotonin system, such as nausea, vomiting, and migraines.
Used in Research Applications:
In the field of research, N-METHYLQUIPAZINE DIMALEATE is used as a selective agonist for studying the role of 5-HT3 receptors in various physiological and pathological processes. Its selective binding to 5-HT3 sites without interacting with 5-HT1B sites makes it a valuable tool for investigating the specific functions and mechanisms of these receptors.
Used in Drug Development:
N-METHYLQUIPAZINE DIMALEATE can be utilized in the development of new drugs targeting the serotonin system, particularly for conditions where 5-HT3 receptor activation is beneficial. Its selective action on 5-HT3 receptors may lead to the creation of more targeted and effective therapies with fewer side effects compared to non-selective agonists.
Biological Activity
5-HT 3 agonist. Has almost the same affinity for 5-HT 3 sites as quipazine but unlike the latter, does not bind to 5-HT 1B sites.
Check Digit Verification of cas no
The CAS Registry Mumber 28614-26-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,6,1 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 28614-26:
(7*2)+(6*8)+(5*6)+(4*1)+(3*4)+(2*2)+(1*6)=118
118 % 10 = 8
So 28614-26-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H17N3/c1-16-8-10-17(11-9-16)14-7-6-12-4-2-3-5-13(12)15-14/h2-7H,8-11H2,1H3/p+2
28614-26-8Relevant articles and documents
Pd-PEPPSI-IPentAn Promoted Deactivated Amination of Aryl Chlorides with Amines under Aerobic Conditions
Huang, Fei-Dong,Xu, Chang,Lu, Dong-Dong,Shen, Dong-Sheng,Li, Tian,Liu, Feng-Shou
, p. 9144 - 9155 (2018/07/21)
We report herein a highly efficient Pd-catalyzed amination by "bulky-yet-flexible" Pd-PEPPSI-IPentAn complexes. The relationship between the N-heterocyclic carbenes (NHCs) structure and catalytic properties was discussed. Sterically hindered (hetero)aryl chlorides and a variety of aliphatic and aromatic amines can be applied in this cross-coupling, which smoothly proceeded to provide desired products. The operationally simple protocol highlights the rapid access to CAr-N bond formation under mild conditions without the exclusion of air and moisture.
Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo
Smits, Rogier A.,Lim, Herman D.,Hanzer, Agnes,Zuiderveld, Obbe P.,Guaita, Elena,Adami, Maristella,Coruzzi, Gabriella,Leurs, Rob,De Esch, Iwan J. P.
, p. 2457 - 2467 (2008/12/22)
Using a previously reported flexible alignment model we have designed, synthesized, and evaluated a series of compounds at the human histamine H 4 receptor (H4R) from which 2-(4-methyl-piperazin-l-yl)- quinoxaline (3) was identified as a new lead structure for H4R ligands. Exploration of the structure-activity relationship (SAR) of this scaffold led to the identification of 6,7-dichloro 3-(4-methylpiperazin-l-yl) quinoxalin-2(1H)-one (VUF 10214, 57) and 2-benzyl-3-(4-methyl-piperazin-l-yl) quinoxaline (VUF 10148, 20) as potent H4R ligands with nanomolar affinities. In vivo studies in the rat reveal that compound 57 has significant anti-inflammatory properties in the carrageenan-induced paw-edema model.
