28663-68-5

Basic information

• Product Name: ETHYL (2E)-CHLORO(PHENYLHYDRAZONO)ACETATE
• Synonyms: ETHYL (2E)-CHLORO(PHENYLHYDRAZONO)ACETATE;2-CHLORO-2-(PHENYLHYDRAZONO)ACETIC ACID ETHYL ETHER;2-Chloro-2-(phenylhydrazono)acetic acid ethyl;Acetic acid, 2-chloro-2-(2-phenylhydrazinylidene)-, ethyl ester
• CAS NO: 28663-68-5
• Molecular Formula: C₁₀H₁₁ClN₂O₂
• Molecular Weight: 226.66
• Mol File: 28663-68-5.mol
• Article Data: 21

Chemical Properties

• Melting Point: 77-80°C
• Boiling Point: 308.7°Cat760mmHg
• Flash Point: 140.5°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 0.00067mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: ETHYL (2E)-CHLORO(PHENYLHYDRAZONO)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL (2E)-CHLORO(PHENYLHYDRAZONO)ACETATE(28663-68-5)
• EPA Substance Registry System: ETHYL (2E)-CHLORO(PHENYLHYDRAZONO)ACETATE(28663-68-5)

Safety Data

• Hazardous Substances Data: 28663-68-5(Hazardous Substances Data)

Usage

Description

ETHYL (2E)-CHLORO(PHENYLHYDRAZONO)ACETATE, also known as 2-Chloro-2-(phenylhydrazono)acetic acid ethyl ester, is an organic compound that serves as a key intermediate in the synthesis of various chemical compounds. It is characterized by its reactivity and ability to form a wide range of derivatives, making it a versatile building block in organic chemistry.

Uses

Used in Pharmaceutical Industry:
ETHYL (2E)-CHLORO(PHENYLHYDRAZONO)ACETATE is used as a synthetic intermediate for the preparation of full-substituted pyrazole derivatives. These pyrazole derivatives are known for their diverse range of biological activities, including anti-inflammatory, antifungal, and antimicrobial properties. They are also used in the development of pharmaceuticals targeting various diseases, such as cancer, diabetes, and neurological disorders.
Used in Chemical Research:
In the field of chemical research, ETHYL (2E)-CHLORO(PHENYLHYDRAZONO)ACETATE is utilized as a starting material for the synthesis of various complex organic molecules. Its unique structure allows for a wide range of reactions, enabling the creation of novel compounds with potential applications in various industries, such as agriculture, materials science, and pharmaceuticals.
Used in Material Science:
ETHYL (2E)-CHLORO(PHENYLHYDRAZONO)ACETATE can be employed in the development of new materials with specific properties, such as improved stability, enhanced reactivity, or tailored physical characteristics. These materials can be used in various applications, including coatings, adhesives, and polymers, where their unique properties can provide advantages over existing materials.

InChI:InChI=1/C10H11ClN2O2/c1-2-15-10(14)9(11)13-12-8-6-4-3-5-7-8/h3-7,12H,2H2,1H3

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 67-56-1 methanol 
• 100-34-5 benzene diazonium chloride 
• 10475-63-5 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester 
• 2684-02-8 benzenediazonium 
• 127-09-3 sodium acetate 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 6415-38-9 benzenediazonium sulphate 
• 938-81-8 N-nitrosoacetanilide 
• 112260-88-5 ethyl dichlorothionoacetate 
• 128100-08-3 (Phenyl-ONN-azoxy)-acetic acid ethyl ester 
• 62-53-3 aniline 
• 7782-50-5 chlorine 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 36999-43-6 ethyl α-amino-α-(phenylhydrazono)glyoxylate 
• 61349-70-0 5,5-di-morpholin-4-yl-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester 
• 56885-96-2 5-(2-oxo-2-p-tolyl-ethylidene)-4-phenyl-4,5-dihydro-[1,3,4]thiadiazole-2-carboxylic acid ethyl ester 
• 39143-38-9 6-tert-butyl-3-ethoxycarbonyl-1,4,4-triphenyl-1,4-dihydro-[1,2,4]diazaphosphininium; chloride 
• 56456-85-0 1,4-Dihydro-1-phenyl-indeno[1,2-c]pyrazole-3-carboxylic acid,ethyl ester 
• 56885-92-8 5-(2-oxo-2-phenyl-ethylidene)-4-phenyl-4,5-dihydro-[1,3,4]thiadiazole-2-carboxylic acid ethyl ester 
• 56886-03-4 2-(2-oxo-2-phenyl-ethylidene)-3-phenyl-thiazolidine-4,5-dione 5-phenylhydrazone 
• 133380-81-1 2-phenylhydrazono-3-oxo-5,6-dihydroimidazo<2.1-b>thiazole 
• 87287-58-9 6-(Phenyl-hydrazono)-1H-imidazo[1,2-b][1,2,4]triazol-5-one 
• 117137-02-7 (4R,5S)-5-Cyano-1,4-diphenyl-4,5-dihydro-1H-pyrazole-3,5-dicarboxylic acid diethyl ester 
• 88860-92-8 1-phenyl-3-ethoxycarbonyl-4-acetylpyrazole 
• 86955-91-1 Ethyl 1-phenyl-4-(trimethylsilyl)pyrazole-3-carboxylate 

Relevant articles and documents

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists

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Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation

Dysregulation of the Wnt/β-catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Although numerous Wnt inhibitors have been developed, they commonly suffer from toxicity and unintended effects. Moreover, concerns have been raised in targeting this pathway because of its critical roles in maintaining stem cells and regenerating tissues and organs. On the basis of the anthelmintic drug pyrvinium and previous lead FX1128, we have developed a compound YW2065 (1c) which demonstrated excellent anti-CRC effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity. The anti-CRC effect of YW2065 was highlighted by its promising efficacy in a mice xenograft model.

5-MEMBERED HETEROCYCLE FUSED WITH [3,4-D]PYRIDAZINONE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF

The present invention provides a compound comprising a 5-membered heterocycle fused with a pyridazinone, wherein the compound is used as an FGFR kinase inhibitor, and a manufacturing method and application thereof. The invention specifically provides a co