287118-97-2 Usage
Chemical Properties
Pale Yellow Solid
Uses
A novel nitric oxide-releasing aspirin,
Biochem/physiol Actions
NCX 4040 is a nitric oxide-donating form of aspirin. NCX 4040 inhibits cyclooxygenase activity and releases NO, which can down-regulate COX2 expression and reduce the levels of superoxide accumulation. In the human monocytic cell line THP1, the compound inhibits PGE2 production and cytokine expression, and appears to stabilize IkB by inhibiting proteasome function. NCX 4040 has been shown to induce apoptosis in several tumor cell lines.
Check Digit Verification of cas no
The CAS Registry Mumber 287118-97-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,1,1 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 287118-97:
(8*2)+(7*8)+(6*7)+(5*1)+(4*1)+(3*8)+(2*9)+(1*7)=172
172 % 10 = 2
So 287118-97-2 is a valid CAS Registry Number.
287118-97-2Relevant articles and documents
COMPOUNDS USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES
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, (2015/04/15)
The present invention refers to compounds of formula: (formula A), wherein R1 is selected from (formula I), (formula II), (formula (III), (formula IV), (formula V), or (formula B), and wherein R2, R3, R4 and Rs
Nitroderivatives as drugs for diseases having an inflammatory basis
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, (2008/06/13)
Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, having the following general formula (I): A-Xt-L-(W)p—NO2 wherein A contains the radical of a drug, Xt and W arc bivalent radicals, L, is a covalent bond or oxygen, sulphur, NRtc wherein Rtc is H or a C1-C5 linear or branched alkyl.
