287176-62-9

Basic information

• Product Name: 6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID, 97
• Synonyms: 6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID, 97;6-Bromo-2-chloroquinoline-4-carboxylic acid;6-bromo-2-chloro-4-Quinolinecarboxylic acid;FUAQFLSUGWLYNC-UHFFFAOYSA-N
• CAS NO: 287176-62-9
• Molecular Formula: C10H5BrClNO2
• Molecular Weight: 286.5092
• Mol File: 287176-62-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 200℃
• Boiling Point: 421.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.819±0.06 g/cm3(Predicted)
• PKA: 1.96±0.30(Predicted)
• CAS DataBase Reference: 6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID, 97(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID, 97(287176-62-9)
• EPA Substance Registry System: 6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID, 97(287176-62-9)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 287176-62-9(Hazardous Substances Data)

Usage

General Description

6-Bromo-2-chloroquinoline-4-carboxylic acid, 97 is a chemical compound with a molecular formula C10H5BrClNO2. It is a derivative of quinoline and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID, 97 is known for its high purity, with a purity level of 97%. It is a pale yellow solid at room temperature and is primarily used in organic synthesis and research. Its applications include the production of anti-inflammatory and anti-cancer drugs, as well as the development of crop protection agents. Additionally, 6-Bromo-2-chloroquinoline-4-carboxylic acid, 97 is known for its stability and compatibility with a wide range of solvents and reagents, making it a versatile and valuable chemical in various industries.

Upstream product

• 5463-29-6 6-bromo-2-hydroxyquinoline-4-carboxylic acid 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors

A series of imidazo[1,5-a]quinoline derivatives was designed and synthesized as central benzodiazepine receptor (CBR) ligands. Most of the compounds showed high CBR affinity with Ki values within the submicromolar and subnanomolar ranges with interesting modulations in their structure-affinity relationships. In particular, fluoroderivative 7w (Ki = 0.44 nM) resulted in the most potent ligand among the imidazo[1,5-a]quinoline derivatives described so far. Overall, these observations confirmed the assumption concerning the presence of a large though apparently saturable lipophilic pocket in the CBR binding site region interacting with positions 4 and 5 of the imidazo[1,5-a]quinoline nucleus. The in vivo biological characterization revealed that compounds 7a,c,d,l,m,q,r,w show anxiolytic and antiamnestic activities without the unpleasant myorelaxant side effects of the classical 1,4-BDZ. Furthermore, the effect of 7l,q,r, and 8i in lowering lactate dehydrogenase (LDH) release induced by ischemia-like conditions in rat brain slices suggested neuroprotective properties for these imidazo[1,5-a]quinoline derivatives.