28721-09-7Relevant articles and documents
Freezing the Butterfly Motion of Carbamazepine Derivatives
Kanase, Yuki,Kuniyoshi, Mai,Tabata, Hidetsugu,Takahashi, Yuka,Kayama, Susumu,Wakamatsu, Shintaro,Oshitari, Tetsuta,Natsugari, Hideaki,Takahashi, Hideyo
, p. 3907 - 3913 (2015/12/18)
Atropisomeric properties were found in carbamazepine derivatives. The atropisomers of N-acyl and N-thiocarbamoyl derivatives of carbamazepine were isolated, with high stereochemical stability. It has been elucidated that the rotation about the N-C1′ axis around the outer amide N-(C=O) does not coordinate with the rotation of the butterfly-like motion.
AN IMPROVED PROCESS FOR THE PREPARATION OF OXCARBAZEPINE
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Page/Page column 9, (2009/12/23)
The present invention relates to an improved process for the preparation of 10-oxo- 10,l l-dihydiO-5H-dibenz[b,fjazepine-5-carboxamide (Oxcarbazepine) by reacting 10-methoxy-5H-dibenz[b,f]azepine (10-methoxyiminostilbene) and alkali metal cyanate in presence of α-hydroxy acids, and also relates to the process for the preparation of carbamazepine from iminostilbene. Further the present invention is directed to the novel crystalline form of 10-methoxy carbamazepine.
Process for the preparation of oxcarbazepine
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Page/Page column 8, (2008/06/13)
The reaction between 10-methoxy-iminostilbene (IV) and of(trichloromethyl)carbonate affords 10-methoxy-N-chlorocarbonyliminostilbene (XVI) in high yields, then ammonolysis and subsequent hydrolysis of the enol ether provides particularly pure oxcarbazepine.