287952-67-4 Usage
Description
4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE is a chemical compound characterized by its unique molecular structure, featuring a piperidine core with a trifluoromethoxyphenoxy substituent. 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE is known for its potential applications in the pharmaceutical industry, particularly in the development of antituberculosis agents.
Uses
Used in Pharmaceutical Industry:
4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE is used as a key intermediate in the synthesis of 3,5-disubstituted isoxazolines, which are considered as potential antituberculosis agents. These agents are being explored for their ability to target and inhibit the growth of Mycobacterium tuberculosis, the causative agent of tuberculosis, a significant global health concern.
4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE's role in the development of antituberculosis agents is attributed to its structural features, which may facilitate the design of new drugs with improved efficacy and reduced side effects compared to existing treatments. By incorporating 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE into the molecular framework of isoxazoline-based drugs, researchers aim to enhance their ability to target and disrupt the vital processes within Mycobacterium tuberculosis, ultimately leading to the inhibition of the disease's progression.
Check Digit Verification of cas no
The CAS Registry Mumber 287952-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,9,5 and 2 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 287952-67:
(8*2)+(7*8)+(6*7)+(5*9)+(4*5)+(3*2)+(2*6)+(1*7)=204
204 % 10 = 4
So 287952-67-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H14F3NO/c13-12(14,15)9-1-3-10(4-2-9)17-11-5-7-16-8-6-11/h1-4,11,16H,5-8H2
287952-67-4Relevant articles and documents
METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF
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Paragraph 0135, (2018/03/25)
The present invention provides a method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof, the method including the step of heating hydroquinone and 4-(4-trifluoromethoxyphenoxy)piperidine. This method can produce 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof in an industrially advantageous manner.
Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity
Lu, Xiaoyun,Tang, Jian,Cui, Shengyang,Wan, Baojie,Franzblauc, Scott G.,Zhang, Tianyu,Zhang, Xiantao,Ding, Ke
, p. 41 - 48 (2016/09/23)
A series of pyrazolo[1,5-a]pyridine-3-carboxamide hybrids were designed and evaluated as novel anti-tubercular agents. The representative hybrid 7 exhibited promising in?vitro activity against susceptive strain H37Rv and a panel of drug-resistant Mtb strains with MIC values of 0.006?μg/mL and ranged from 0.003 to 0.014?μg/mL, respectively. More importantly, the hybrid 7 also showed very low cytotoxicity, and could significantly reduce the mycobacterial burden in a mouse model infected with autoluminescent H37Ra strain, which may serve as a lead compound for further development of new anti-tubercular agents.
(6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6-YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
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, (2013/04/10)
(6,7-Dihydro-2-nitro-5H-imidazo [2,1-b][1,3]oxazin-6-yl)amide compounds of formula (I), and their pharmaceutically acceptable salts, preparation methods and pharmaceutical compositions thereof are disclosed, wherein m and R are defined as in the descripti
