288-37-9 Usage
Description
1,2,5-Oxadiazole is a five-membered, heteroaromatic, planar heterocycle comprised of one oxygen atom with two vicinal nitrogen atoms (N-O-N) and two carbon atoms at the 3and 4-positions of the ring. It is a π-excessive heterocycle also referred to by its trivial name furazan and corresponding 2-N-oxide as furoxan. The ionization energy of oxadiazole is 11.79 eV and the dipole moment is 3.38 D greater than isoxazole. The π electron density of the nitrogen atom is greater than the oxygen and carbon atoms.
Uses
Used in Pharmaceutical Industry:
1,2,5-Oxadiazole is used as a potent inhibitor for indoleamine 2,3-dioxygenase, which is useful for the treatment of cancer and other disorders. It is also useful as a new class of SENP2 inhibitors and can be used for the development of novel therapeutic agents for various diseases targeting SENPs.
Used in Biological Studies:
1,2,5-Oxadiazole-2-oxides are used as a source of NO (Nitric Oxide) in biological studies, which can be beneficial for understanding various biological processes and mechanisms.
Used in Cardiovascular Research:
4-Amino-1,2,5-oxadiazole-2-oxide-3-carboxylic acid and azo derivatives have been studied for their vasodilating properties, which can be useful in the development of treatments for cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 288-37-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,8 and 8 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 288-37:
(5*2)+(4*8)+(3*8)+(2*3)+(1*7)=79
79 % 10 = 9
So 288-37-9 is a valid CAS Registry Number.
InChI:InChI=1/C2H2N2O/c1-2-4-5-3-1/h1-2H
288-37-9Relevant articles and documents
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Olofson,Michelman
, p. 1854,1858 (1965)
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Substituted amino methyl factor Xa inhibitors
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, (2008/06/13)
The present application describes substituted-aminomethyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
Heteroaryl- phenyl heterobicyclic factor Xa inhibitors
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, (2008/06/13)
The present application describes heteroaryl-phenyl heterobicycles and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
