288071-97-6

Basic information

• Product Name: (E)-2-Benzotriazol-1-yl-3-(4-chloro-phenyl)-acrylonitrile
• Synonyms: (E)-2-Benzotriazol-1-yl-3-(4-chloro-phenyl)-acrylonitrile
• CAS NO: 288071-97-6
• Molecular Weight: 280.716
• Mol File: 288071-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-Benzotriazol-1-yl-3-(4-chloro-phenyl)-acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-Benzotriazol-1-yl-3-(4-chloro-phenyl)-acrylonitrile(288071-97-6)
• EPA Substance Registry System: (E)-2-Benzotriazol-1-yl-3-(4-chloro-phenyl)-acrylonitrile(288071-97-6)

Safety Data

• Hazardous Substances Data: 288071-97-6(Hazardous Substances Data)

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 104-88-1 4-chlorobenzaldehyde 
• 111198-08-4 1-(cyanomethyl)benzotriazole 

Relevant articles and documents

Synthesis and antitubercular activity of 3-aryl substituted-2-(1H(2H) benzotriazol-1(2)-yl)acrylonitriles

A series of 223-aryl substituted-2-(1H(2H)-benzotriazol-1(2)- yl)acrylonitriles was synthesized for a preliminary in vitro evaluation of antitubercular activity according to an international program with the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF). This work reports the synthetic approach and analytical and spectroscopic characterization (UV, IR, 1H- and 13C-NMR) of all compounds synthesized. Several compounds showed an interesting activity in the preliminary screening with a percent growth inhibition of the virulent Mycobacterium tuberculosis between 40 and 99% at the concentration of 12.5 μg/mL. The most effective derivatives E-5a and E-5e were also tested against M. avium in vitro. (C) 2000 Editions scientifiques et medicales Elsevier SAS.