289684-54-4

Basic information

• Product Name: 7-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-3,9-dioxo-1,4,7,10tetraaza-cyclododecane-1-carboxylic acid benzyl ester
• Synonyms: 7-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-3,9-dioxo-1,4,7,10tetraaza-cyclododecane-1-carboxylic acid benzyl ester
• CAS NO: 289684-54-4
• Molecular Weight: 500.511
• Mol File: 289684-54-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-3,9-dioxo-1,4,7,10tetraaza-cyclododecane-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-3,9-dioxo-1,4,7,10tetraaza-cyclododecane-1-carboxylic acid benzyl ester(289684-54-4)
• EPA Substance Registry System: 7-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-3,9-dioxo-1,4,7,10tetraaza-cyclododecane-1-carboxylic acid benzyl ester(289684-54-4)

Safety Data

• Hazardous Substances Data: 289684-54-4(Hazardous Substances Data)

Upstream product

• 289684-52-2 3,9-dioxo-1,4,7,10tetraaza-cyclododecane-1,7-dicarboxylic acid 1-benzyl ester 7-(9H-fluoren-9-ylmethyl) ester 
• 203643-36-1 {(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester 
• 139166-80-6 N-(2-t-butoxycarbonylaminoethyl)-N-(thymin-1-ylacetyl)glycine 
• 34046-07-6 N-benzyloxycarbonyl-N-(2-t.butoxycarbonylaminoethyl)glycine 
• 20924-05-4 thymidyl acetic acid 
• 289684-53-3 3,9-Dioxo-1,4,7,10-tetraaza-cyclododecane-1-carboxylic acid benzyl ester 
• 289684-71-5 {benzyloxycarbonyl-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid methyl ester 
• 289684-72-6 {(2-{2-[benzyloxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetylamino}-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester 

Downstream Products

• 289684-56-6 N-[9-(2-{7-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-3,9-dioxo-1,4,7,10tetraaza-cyclododec-1-yl}-2-oxo-ethyl)-9H-purin-6-yl]-benzamide 

Relevant articles and documents

An expeditious liquid-phase synthesis of cyclic peptide nucleic acids

Suitably protected linear precursors of cyclic PNAs can be readily obtained by BOP/DiPEA coupling of the corresponding sub-monomers. Conversion of the linear PNA dimers into the pentafluorophenyl esters allows cyclization by intramolecular attack of the deprotected primary amino function under diluted conditions. After removal of the secondary amino protecting group(s), installation of the required nucleobase-acetyl function(s) affords cyclic PNAs. In addition, the latter compounds can be prepared following a direct coupling strategy. (C) 2000 Elsevier Science Ltd.