2901-44-2

Basic information

• Product Name: [4-(acetylamino)cyclohexyl]acetic acid
• CAS NO: 2901-44-2
• Molecular Formula: C₁₀H₁₇NO₃
• Molecular Weight: 199.2469
• Mol File: 2901-44-2.mol
• Article Data: 4

Chemical Properties

• Refractive Index: 1.499
• CAS DataBase Reference: [4-(acetylamino)cyclohexyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(acetylamino)cyclohexyl]acetic acid(2901-44-2)
• EPA Substance Registry System: [4-(acetylamino)cyclohexyl]acetic acid(2901-44-2)

Safety Data

• Hazardous Substances Data: 2901-44-2(Hazardous Substances Data)

Usage

General Description

[4-(acetylamino)cyclohexyl]acetic acid is a chemical compound that belongs to the class of acetic acid derivatives. It is a white to off-white crystalline solid with a molecular formula of C12H19NO3. [4-(acetylamino)cyclohexyl]acetic acid is commonly used in the synthesis of various pharmaceuticals and organic compounds due to its ability to modify the properties of other chemicals. It can also act as a building block for the preparation of other functionalized acetic acid derivatives. The acetylamino group present in the compound plays a crucial role in its reactivity and biological activity, making it a valuable component in the field of organic chemistry.

Upstream product

• 18699-02-0 4-acetamidophenylacetic acid 
• 27514-08-5 N-(4-oxocyclohexyl)acetamide 
• 90978-94-2 Actarit 

Downstream Products

• 946598-99-8 trans-ethyl 2-(4-acetamidocyclohexyl)acetate 
• 2952-00-3 trans-2-(4-aminocyclohexyl)acetic acid 
• 61367-24-6 {4-[3-(2-Chloro-ethyl)-ureido]-cyclohexyl}-acetic acid 
• 52320-89-5 C₁₁H₁₈ClN₃O₄ 

Relevant articles and documents

NOVEL PROCESSES FOR THE PREPARATION OF TRANS-N-{4-[2-[4-(2,3-DICHLOROPHENYL)PIPERAZINE-1-YL]ETHYL] CYCLOHEXYL}-N',N'-DIMETHYLUREA HYDROCHLORIDE AND POLYMORPHS THEREOF

The present invention relates to novel processes for the preparation of trans- N-{4-[2- [4-(2,3-dichloro phenyl) piperazine-1-yl] ethyl] cyclohexyl} -N',N'-dimethylurea hydrochloride represented by the following structural formula-1a and polymorphs thereof. (I) The present invention also relates to novel intermediate compounds which are useful for the preparation of compound of formula-1a.

Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents

The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.