2904-67-8

Basic information

• Product Name: 1-phenyl-3-(2,4,6-trimethylphenyl)urea
• Synonyms: 1-Mesityl-3-phenylurea; urea, N-phenyl-N'-(2,4,6-trimethylphenyl)-
• CAS NO: 2904-67-8
• Molecular Formula: C₁₆H₁₈N₂O
• Molecular Weight: 254.3269
• Mol File: 2904-67-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 305.5°C at 760 mmHg
• Flash Point: 93.2°C
• Density: 1.163g/cm³
• Vapor Pressure: 0.000818mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 1-phenyl-3-(2,4,6-trimethylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-(2,4,6-trimethylphenyl)urea(2904-67-8)
• EPA Substance Registry System: 1-phenyl-3-(2,4,6-trimethylphenyl)urea(2904-67-8)

Safety Data

• Hazardous Substances Data: 2904-67-8(Hazardous Substances Data)

Usage

Physical appearance

White crystalline the compound forms solid crystals that are white in color.

Solubility

Sparingly soluble in water the compound does not dissolve easily in water.

Usage

Reagent in organic synthesis PTU is often used as a reagent to help create other organic compounds in chemical reactions.

Properties

Anti-microbial and anti-inflammatory PTU has been shown to possess properties that can inhibit the growth of microorganisms and reduce inflammation.

Biological research application

Thyroid peroxidase inhibitor PTU is used in the study of thyroid function and autoimmune thyroid disease, as it can inhibit the activity of thyroid peroxidase, an enzyme involved in thyroid hormone production.

Upstream product

• 103-71-9 phenyl isocyanate 
• 88-05-1 2,4,6-trimethylaniline 
• 60986-29-0 N-(2,4,6-trimethylphenyl)-N′-phenylcarbodiimide 
• 2958-62-5 mesityl isocyanate 
• 62-53-3 aniline 
• 2904-57-6 mesitylenecarbonitrile oxide 
• 37143-74-1 1-mesityl-3-phenylthiourea 
• 65-85-0 benzoic acid 
• 72340-27-3 N-(2,4,6-Trimethyl-phenyl)-benzamidine 
• 3023-19-6 N-hydroxy-2,4,6-trimethyl-N'-phenyl-benzamidine 
• 63133-66-4 3-phenyl-4-(2,4,6-trimethyl-phenyl)-3H-[1,2,3,5]oxathiadiazole 2-oxide 
• 201230-82-2 carbon monoxide 
• 622-37-7 Phenyl azide 
• 480-63-7 mesitylenecarboxylic acid 

Relevant articles and documents

Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions

Symmetrical and unsymmetrical N,N’-disubstituted as well as trisubstituted ureas/thioureas by the hydroamination of isocyanates/isothiocyanates, and various phosphathioureas by the hydrophosphination of isothiocyanates have been synthesized in good to excellent yields under catalyst-free and mild conditions. This protocol is also applicable for the efficient synthesis of chiral ureas and thioureas and common herbicides, such as fenuron and monuron.

2-Picolylamino(diphenylphosphinoselenoic)amide supported zinc complexes: Efficient catalyst for insertion of N–H bond into carbodiimides, isocyanates, and isothiocyanate

We report here the hydroamination of heterocumulenes such as carbodiimides, isocyanates, and isothiocyanates by zinc complexes supported by the ligand 2-picolylamino-(diphenylphosphinoselenoic)amide [{(Ph2P-(?Se)}2NCH2(C5H4N)] (1). A series of zinc complexes [κ2-{(Ph2P-(?Se)}2NCH2(C5H4N)ZnX2] [(X?Cl (2), Br (3a), I (4)] were prepared from ligand 1 and the corresponding zinc dihalide in a 1:1 molar ratio at 60°C in a chloroform solvent. The reaction of ligand 1 and ZnBr2 in methanol yielded another zinc complex [κ2-{(Ph2P-(?Se)}2NCH2(C5H4N)ZnBr2(CH3OH)] (3b). The molecular structures of compounds 3a, 3b, and 4 were established through single-crystal X-ray diffraction analyses. The solid-state structures of all the complexes revealed a κ2- chelation through pyridine nitrogen and selenium atoms of ligand 1 to the zinc ion. Complex 2 proved to be a competent pre-catalyst for the addition of the amine N–H bond to carbodiimides, isocyanates, and isothiocyanates. The reaction scope was expanded to reactions of aliphatic and aromatic amines with phenylisocyanate and phenylisothiocyanate in toluene solvents, which proceeded rapidly at room temperature with 5 mol% catalyst loading to yield (up to 99%) the corresponding derivatives of urea and thio-urea. However, a temperature of 90°C was needed for the hydroamination of N,N′ dicyclohexylcarbodiimide. We also report the most plausible mechanism of the hydroamination reaction.

Pd/C Catalyzed Carbonylation of Azides in the Presence of Amines

A facile and efficient Pd/C-catalyzed carbonylation of both aliphatic and aromatic azides in the presence of amines is reported. Serving as the widely existed fragments in an array of biological pharmaceuticals, functionalized unsymmetrical ureas were str