29083-16-7

Basic information

• Product Name: 5-CHLOROSACCHARIN
• Synonyms: 5-CHLOROSACCHARIN
• CAS NO: 29083-16-7
• Molecular Formula: C₇H₄ClNO₃S
• Molecular Weight: 217.62956
• Mol File: 29083-16-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.679g/cm³
• Refractive Index: 1.641
• CAS DataBase Reference: 5-CHLOROSACCHARIN(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROSACCHARIN(29083-16-7)
• EPA Substance Registry System: 5-CHLOROSACCHARIN(29083-16-7)

Safety Data

• Hazardous Substances Data: 29083-16-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H4ClNO3S/c8-4-1-2-6-5(3-4)7(10)9-13(6,11)12/h1-3H,(H,9,10)

Upstream product

• 29083-09-8 2-tert-butylsulfamoyl-5-chloro-benzoic acid 
• 29632-79-9 5-chloro-3,3-difluoro-3H-benzo[c][1,2]oxathiole 1,1-dioxide 
• 85019-87-0 5-chloro-2-methyl-benzenesulfonamide 
• 5202-89-1 4-chlorobenzenesulfonyl chloride 
• 108-41-8 1-chloro-3-methylbenzene 
• 56157-92-7 5-chloro-3-methylbenzene-2-sulphonyl chloride 

Relevant articles and documents

Synthesis of 3,4-dihydro-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxides and their evaluation as ligands for NMDA receptor glycine binding site

A series of 2-substituted 3,4-dihydro-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxides were synthesized and evaluated for their affinity to the glycine binding site of the N-methyl-d-aspartate (NMDA) receptor. The binding affinity was determined by the displacement of radioligand [3H]MDL-105,519 from rat cortical membrane preparations. The most attractive structures in the search for prospective NMDA receptor ligands were identified to be 2-arylcarbonylmethyl substituted 3,4-dihydro-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxides. It has been demonstrated for the first time that the replacement of NH group in the ligand by sp3 CH2 is tolerated. This finding may pave the way for previously unexplored approaches for designing new ligands of the NMDA receptor.

Oxidative cyclization of N-alkyl-o-methyl-arenesulfonamides to biologically important saccharin derivatives

Various biologically important saccharin skeletons and their N-alkyl derivatives have been efficiently prepared by chromium(VI) oxide catalyzed H5IO6 oxidation of N-alkyl-o-methyl-arenesulfonamides in acetonitrile. N-tert-Butyl saccharin skeletons were easily prepared by H5IO6-CrO3 oxidation of N-tert-butyl-o-methyl arenesulfonamides in the presence of acetic anhydride. The method that furnished the novel fluoro and trifluoromethyl substituted saccharin skeletons is characterized by two steps, a simple work-up procedure, a single purification and good overall yields from substituted toluene derivatives.

The Reaction of Saccharin Derivatives with N,N-Diethylprop-1-ynamine: Formation of Cyclobutenyl Saccharinates and of a Spiro-oxete

Saccharin and two equivalents of N,N-diethylprop-1-ynamine give a cyclobutenyl saccharinate (4) which, on bromination, gives the N-(cyclobutenyl cation)saccharin derivative (8), whose structure was established by X-ray crystallography ; N-methylsaccharin reacts with one equivalent of ynamine to yield the spiro-oxete (9): this represents the second isolation of such a stable oxete from reaction of an ynamine with a carbonyl group.