29261-25-4

Basic information

• Product Name: d-Clorprenaline
• Synonyms: (S)-Clorprenaline;Benzenemethanol, 2-chloro-α-[[(1-methylethyl)amino]methyl]-, (S)-;Benzenemethanol, 2-chloro-α-[[(1-methylethyl)amino]methyl]-, (αS)-;Benzyl alcohol, o-chloro-α-[(isopropylamino)methyl]-, (+)- (8CI);d-Clorprenaline
• CAS NO: 29261-25-4
• Molecular Formula: C11H16ClNO
• Molecular Weight: 213.70384
• Mol File: 29261-25-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: d-Clorprenaline(CAS DataBase Reference)
• NIST Chemistry Reference: d-Clorprenaline(29261-25-4)
• EPA Substance Registry System: d-Clorprenaline(29261-25-4)

Safety Data

• Hazardous Substances Data: 29261-25-4(Hazardous Substances Data)

Upstream product

• 75-31-0 isopropylamine 
• 27993-71-1 1-(2-chlorophenyl)-2-hydroxyethanone 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 23496-56-2 (+/-)-2-amino-1-(2-chlorophenyl)ethanol 
• 67-64-1 acetone 
• 5000-66-8 2-chlorophenacyl bromide 
• 855300-90-2 C₁₀H₈ClNO₃ 
• 6933-90-0 Clorprenaline hydrochloride 
• 3811-25-4 clorprenaline 
• 62717-50-4 o-chlorostyrene oxide 
• 62717-50-4 (R)-(-)-2-(2-chlorophenyl)oxirane 
• 4209-25-0 2-chloro-1-(2-chlorophenyl)ethanone 

Relevant articles and documents

Preparation of a novel hydroxypropyl-γ-cyclodextrin functionalized monolith for separation of chiral drugs in capillary electrochromatography

In this study, a novel hydroxypropyl-γ-cyclodextrin (HP-γ-CD) functionalized monolithic capillary column was prepared by one-pot sequential strategy and used for chiral separation in capillary electrochromatography for the first time. In one pot, GMA-HP-γ-CD as functional monomer was allowed to be formed via the ring opening reaction between HP-γ-CD and glycidyl methacrylate (GMA) catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and then copolymerized directly with ethylene dimethacrylate (EDMA) and 2-acrylamido-2-methyl propane sulfonic acid (AMPS) in the presence of porogenic solvents via thermally initiated free radical polymerization. The preparation conditions of monoliths were optimized. Enantiomer separations of six chiral drugs including pindolol, clorprenaline, tulobuterol, clenbuterol, propranolol, and tropicamide were achieved on the monolith. Among them, pindolol, clorprenaline, and tropicamide were baseline separated with resolution values of 1.62, 1.73, and 1.55, respectively. The mechanism of enantiomer separation was discussed by comparison of the HP-γ-CD and HP-β-CD functionalized monoliths.

Method for preparing beta-arylamino alcohol drugs such as tulobuterol, clorprenaline, dichloroisoprenaline and sotalol

The invention provides a method for preparing beta-arylamino alcohol drugs such as tulobuterol, clorprenaline, dichloroisoprenaline and sotalol. The beta-arylamino alcohol drugs have a chemical structure represented by a formula 4 shown in the description. The method comprises the following steps: (1) reacting arylethanone represented by a formula 1 shown in the description with a halogenating agent and sulfoxide to obtain arylglyoxal represented by a formula 2 shown in the description and or 1,1-dihydroxyarylethanone represented by a formula 3 shown in the description; and (2) performing a nucleophilic addition reaction on the arylglyoxal represented by the formula 2 and/or the 1,1-dihydroxyarylethanone represented by the formula 3 and an amine compound having a chemical formula of R1-NH2, and performing a reductive amination reaction in the presence of a reducing agent to obtain the beta-arylamino alcohol drugs.

Method for preparing clorprenaline optical isomers based on chiral liquid chromatography

The invention provides a method for preparing clorprenaline optical isomers based on chiral liquid chromatography, comprising the specific steps: 1), preparing a sample; 2) determining chiral chromatographic separation conditions, and preparing under medium pressure; 3), collecting optical isomers respectively, and lyophilizing; 4), measuring purity of the optical isomers. Chiral liquid chromatography is selected to prepare clorprenaline optical isomers for the purpose of solving the problem that synthesis of optically pure clorprenaline in actual scientific research and production is high in difficulty and high in preparation cost, preparation of optical isomers is available for both clorprenaline and its salts, the method has the advantages of good operation simplicity, high preparation efficiency, low cost, high optical purity and the like, the method is applicable particularly to the preparation of high-performance low-toxicity optically pure clorprenaline required by medical industry, corresponding quality control standards may be established for preparation, the method is more widely applicable, and a new concept and method is provided for the research and development, production and quality control for optically pure clorprenaline.