292870-53-2 Usage
Description
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID is a complex organic compound with a unique molecular structure. It is characterized by its dioxoisoindoline-5-carboxylic acid core, which is substituted with a 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl group. 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID has potential applications in various fields due to its specific chemical properties and interactions.
Uses
Used in Pharmaceutical Research:
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID is used as a research compound for studying the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein expression. Its unique structure allows it to interact with specific biological targets, making it a valuable tool in understanding the underlying mechanisms of various diseases and potential therapeutic interventions.
Used in Cancer Research:
In the field of cancer research, 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID is used as a control in studying BAP1 (BRCA1-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma. Its role in this context helps researchers understand the molecular pathways involved in cancer cell death and the potential development of targeted therapies.
Used in Drug Delivery Systems:
2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID may also be utilized in the development of novel drug delivery systems. Its specific chemical properties could be harnessed to improve the delivery, bioavailability, and therapeutic outcomes of various drugs, particularly in the treatment of cancer and other diseases.
Used in Chemical Synthesis:
In the chemical industry, 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID can be used as a starting material or intermediate in the synthesis of other complex organic compounds. Its unique structure and reactivity make it a valuable component in the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Material Science:
The unique properties of 2-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID may also find applications in material science. Its potential use in the development of new materials with specific properties, such as improved stability, reactivity, or selectivity, could have significant implications in various industries, including electronics, coatings, and adhesives.
Biochem/physiol Actions
BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes.
Check Digit Verification of cas no
The CAS Registry Mumber 292870-53-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,2,8,7 and 0 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 292870-53:
(8*2)+(7*9)+(6*2)+(5*8)+(4*7)+(3*0)+(2*5)+(1*3)=172
172 % 10 = 2
So 292870-53-2 is a valid CAS Registry Number.
292870-53-2Relevant articles and documents
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02
Iralde-Lorente, Leire,Cau, Ylenia,Clementi, Letizia,Franci, Lorenzo,Tassone, Giusy,Valensin, Daniela,Mori, Mattia,Angelucci, Adriano,Chiariello, Mario,Botta, Maurizio
, p. 657 - 664 (2019)
14-3-3 are regulatory proteins that through protein–protein interactions (PPI) with numerous binding partners could be involved in several human diseases, including cancer, neurodegenerative disorders, and pathogens infections. Following our research inte
