29289-16-5

Basic information

• Product Name: N-(2-iodo-4-methylphenyl)acetamide
• Synonyms: N-(2-iodo-4-methylphenyl)acetamide
• CAS NO: 29289-16-5
• Molecular Weight: 275.089
• Mol File: 29289-16-5.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: N-(2-iodo-4-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-iodo-4-methylphenyl)acetamide(29289-16-5)
• EPA Substance Registry System: N-(2-iodo-4-methylphenyl)acetamide(29289-16-5)

Safety Data

• Hazardous Substances Data: 29289-16-5(Hazardous Substances Data)

Upstream product

• 103-89-9 4-Methylacetanilide 
• 142-71-2 copper diacetate 
• 106-49-0 p-toluidine 
• 52488-29-6 2-iodo-4-methyl-1-nitrobenzene 
• 64-19-7 acetic acid 
• 29289-13-2 2-iodo-4-methylaniline 
• 75-36-5 acetyl chloride 
• 614-83-5 2-bromo-4-methylacetanilide 
• 108-24-7 acetic anhydride 

Downstream Products

• 960119-61-3 N-ethyl-2-iodo-4-methylaniline 
• 1333345-55-3 N-(cyclohex-2-en-1-yl)-N-(2-iodo-4-methylphenyl)acetamide 
• 1607823-43-7 methyl4-methyl-2-((trimethylsilyl)ethynyl)phenylcarbamate 
• 123028-15-9 2-(1-hexynyl)-4-methyl-N-ethanoylaniline 
• 104683-00-3 N-(4-methyl-2-(phenylethynyl)phenyl)acetamide 
• 36804-51-0 1-(5-methyl-2,3-diphenyl-1H-indol-1-yl)ethan-1-one 
• 1620284-79-8 N-(4-methyl-2-((trifluoromethyl)thio)phenyl)acetamide 

Relevant articles and documents

Solvent-Free and Liquid-Phase Iodination of Thiophene Derivatives with Potassium Dichloroiodate Monohydrate

Iodination of a series of benzene and thiophene derivatives by potassium dichloroiodate monohydrate was studied with and without a solvent. The liquid substrates tend to be more reactive in water while the solid substrates afford better yields in dichloromethane or under the solvent-free conditions. The 2-substituted thiophenes show good to excellent yields whereas the yield for 3-substituted and 3,4- or 2,4-disubstituted thiophenes and benzene derivatives are significantly lower. The mechanochemical reaction of 5-carbaldehyde-2,2′-bithiophene shows excellent yields, while 2,2′-bithiophene gives practical yields only in dichloromethane. In the case of thiophene and N -acetyl- p -toluidine, electrophilic iodination is accompanied by a small extent of chlorination.

Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.

Palladium-catalyzed ortho-halogenations of acetanilides with N-halosuccinimides via direct sp2 C–H bond activation in ball mills

A solvent-free palladium-catalyzed ortho-iodination of acetanilides using N-iodosuccinimide as the iodine source has been developed under ball-milling conditions. This present method avoids the use of hazardous organic solvents, high reaction temperature,