293744-67-9

Basic information

• Product Name: 5-hydroxy-N-p-tolyl-2-trimethylsilanylethynyl-benzamide
• Synonyms: 5-hydroxy-N-p-tolyl-2-trimethylsilanylethynyl-benzamide
• CAS NO: 293744-67-9
• Molecular Weight: 323.467
• Mol File: 293744-67-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-hydroxy-N-p-tolyl-2-trimethylsilanylethynyl-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-N-p-tolyl-2-trimethylsilanylethynyl-benzamide(293744-67-9)
• EPA Substance Registry System: 5-hydroxy-N-p-tolyl-2-trimethylsilanylethynyl-benzamide(293744-67-9)

Safety Data

• Hazardous Substances Data: 293744-67-9(Hazardous Substances Data)

Upstream product

• 197141-51-8 2-iodo-5-hydroxy-N-p-tolyl benzamide 
• 1066-54-2 trimethylsilylacetylene 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 57772-57-3 5-hydroxy-2-iodo-benzoic acid 

Relevant articles and documents

Palladium-catalysed heteroannulation with terminal alkynes: A highly regio- and stereoselective synthesis of (Z)-3-aryl(alkyl)idene isoindolin-1- ones

A highly regio- and stereoselective method for the synthesis of (Z)-3- aryl(alkyl)idene isoindolin-1-ones through palladium-copper catalysis is described. 2-Iodobenzamide 1 and its substituted derivatives 2-10 were reacted with terminal alkynes 11-19 in the presence of (PPh3)2PdCl2, CuI, and Et3N in DMF mostly at 80°C for 16 h to yield the 2-alkynyl substituted benzamides 20-38, 40-45, 77 which could then be cyclised with NaOEt in EtOH to the 3-aryl(alkyl)idene isoindolin-1-ones 46-49, 51, 53-55, 57, 59-71, 73 and 75. In certain cases, the isoindolin-1-ones 50, 52, 56 and 58 could be directly obtained by the palladium-catalysed reactions. (C) 2000 Elsevier Science Ltd.