294194-40-4

Basic information

• Product Name: N-(4-chlorophenyl)-4-nitro-1-methyl-1H-pyrazole-5-carboxamide
• Synonyms: N-(4-chlorophenyl)-4-nitro-1-methyl-1H-pyrazole-5-carboxamide
• CAS NO: 294194-40-4
• Molecular Formula: C₁₁H₉ClN₄O₃
• Molecular Weight: 280.66716
• Mol File: 294194-40-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-chlorophenyl)-4-nitro-1-methyl-1H-pyrazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-4-nitro-1-methyl-1H-pyrazole-5-carboxamide(294194-40-4)
• EPA Substance Registry System: N-(4-chlorophenyl)-4-nitro-1-methyl-1H-pyrazole-5-carboxamide(294194-40-4)

Safety Data

• Hazardous Substances Data: 294194-40-4(Hazardous Substances Data)

Upstream product

• 92534-69-5 1-methyl-4-nitro-1H-pyrazole-5-carboxylic acid 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 1006962-20-4 1-methyl-4-nitro-1H-pyrazole-5-carbonyl chloride 
• 106-47-8 4-chloro-aniline 

Relevant articles and documents

ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2

We have developed a series of novel potent ortho-substituted azole derivatives active against kinases VEGFR-1 and VEGFR-2. Both specific and dual ATP-competitive inhibitors of VEGFR-2 were identified. Kinase activity and selectivity could be controlled by varying the arylamido substituents at the azole ring. The most specific molecule (17) displayed >10-fold selectivity for VEGFR-2 over VEGFR-1. Compound activities in enzymatic and cell-based assays were in the range of activities for reported clinical and development candidates (IC50 30 × 10-5 cm/min) is indicative of their potential for intestinal absorption upon oral administration.