294203-79-5Relevant articles and documents
Cationic zirconocene- or hafnocene-based Lewis acids in organic synthesis: Glycoside-flavonoid analogy
Ohmori, Ken,Hatakeyama, Keisuke,Ohrui, Hiroki,Suzuki, Keisuke
, p. 1365 - 1373 (2007/10/03)
Cationic metallocene species, generated from Cp2MCl2 and AgClO4 (M=Zr, Hf), were used for the glycosylation of catechin derivative 2, enabling a concise synthesis of a glycosyl flavonoid, astilbin (1). Further study revealed the efficiency of this Lewis acidic species for SN1-type activation of the C(4) position of catechin derivative 11, enabling selective substitution with various nucleophiles.
First synthesis of astilbin, biologically active glycosyl flavonoid isolated from Chinese folk medicine
Ohmori, Ken,Ohrui, Hiroki,Suzuki, Keisuke
, p. 5537 - 5541 (2007/10/03)
A synthetic route to a biologically active glycosyl flavonoid, astilbin (1), was developed. The tetra-benzyl ether 4, derived from (+)-catechin, was glycosylated with the L-rhamnosyl donor 10 by using Cp2HfCl2-AgClO4, and subsequent oxidation of the C(4)position of the flavan skeleton followed by deprotection gave 1. (C) 2000 Elsevier Science Ltd.