29424-96-2

Basic information

• Product Name: 4',7-Di-O-methylnaringenin
• Synonyms: 4',7-Di-O-methylnaringenin;(S)-5-Hydroxy-7,4'-dimethoxyflavanone;2,3-Dihydro-5-hydroxy-4',7-dimethoxyflavone;(S)-5-Hydroxy-7-Methoxy-2-(4-Methoxyphenyl)chroMan-4-one;(?)-5-Hydroxy-4′,7-dimethoxyflavanone;(S)-2,3-Dihydro-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;Naringenin 4′,7-dimethyl ether;Sakuranetin 4′-methyl ether
• CAS NO: 29424-96-2
• Molecular Formula: C₁₇H₁₆O₅
• Molecular Weight: 300.30594
• Mol File: 29424-96-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 524.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.281±0.06 g/cm3(Predicted)
• Storage Temp.: ?20°C
• PKA: 7.40±0.40(Predicted)
• CAS DataBase Reference: 4',7-Di-O-methylnaringenin(CAS DataBase Reference)
• NIST Chemistry Reference: 4',7-Di-O-methylnaringenin(29424-96-2)
• EPA Substance Registry System: 4',7-Di-O-methylnaringenin(29424-96-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-45
• WGK Germany: 3
• Hazardous Substances Data: 29424-96-2(Hazardous Substances Data)

Usage

General Description

4',7-Di-O-methylnaringenin is a natural chemical compound found in plants, specifically in citrus fruits such as oranges and grapefruits. It belongs to the flavonoid class of compounds and is known for its potential health benefits, including antioxidant and anti-inflammatory properties. Research has shown that 4',7-Di-O-methylnaringenin may have a role in reducing the risk of cancer and cardiovascular diseases, as well as improving metabolic health. Additionally, it has been investigated for its potential to alleviate menopausal symptoms and osteoporosis. Overall, 4',7-Di-O-methylnaringenin is an important bioactive compound with promising therapeutic potential.

Upstream product

• 480-41-1 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-on 
• 77-78-1 dimethyl sulfate 
• 480-43-3 5,7-dihydroxy-2-(4-methoxyphenyl)chroman-4-one 
• 520-29-6 5,4'-dihydroxy-7-methoxyflavanone 
• 94441-99-3 1-(2,6-dihydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 186581-53-3 diazomethane 
• 74-88-4 methyl iodide 
• 491-69-0 (2S)-poncirenin 
• 3420-72-2 2'-hydroxy-4,4',6'-trimethoxychalcone 
• 17176-17-9 S-Adenosylmethionine 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 66074-95-1 4',5,7-trimethoxyflavanone 
• 3420-72-2 flavokawain A 

Downstream Products

• 5128-44-9 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 35241-54-4 2',6'-dihydroxy-4',4-dimethoxy-dihydrochalcone 
• 94441-99-3 1-(2,6-dihydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 109248-50-2 2,3-dihydro-5,8-dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4-benzopyranone 
• 126116-58-3 2'-(carboxy)methoxy-6'-hydroxy-4,4'-dimethoxydihydrochalcone 
• 126116-57-2 2'-(ethoxycarbonyl)methoxy-6'-hydroxy-4,4'-dimethoxydihydrochalcone 
• 126116-59-4 acetylglycyl>glycine ethyl ester 
• 126116-64-1 N-benzyloxycarbonyl-O-<(6'-hydroxy-4,4'-dimethoxydihydrochalcone)-2'-yl>homoserine 
• 126116-63-0 N-benzyloxycarbonyl-O-<(6'-hydroxy-4,4'-dimethoxydihydrochalcone)-2'-yl>homoserine methyl ester 
• 126116-69-6 homoseryl>glycine 
• 126116-68-5 N-benzyloxycarbonyl-homoseryl>glycine ethyl ester 
• 126116-56-1 Acetic acid (2R,3R,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-{3-hydroxy-5-methoxy-2-[3-(4-methoxy-phenyl)-propionyl]-phenoxy}-tetrahydro-pyran-4-yl ester 
• 126116-66-3 homoseryl>glycine benzyl ester 
• 126116-61-8 N^α-benzyloxycarbonyl-N^ε-<(6'-hydroxy-4,4'-dimethoxydihydrochalcone)-2'-yloxy>acetyl-L-lysine benzyl ester 

Relevant articles and documents

Semisynthesis of prunetin, a bioactive O-methylated isoflavone from naringenin, by the sequential deacetylation of chalcone intermediates and oxidative rearrangement

Prunetin (4′,5-dihydroxy-7-methoxyisoflavone) was semisynthesized in 8 steps from readily available naringenin in 26% total yield. The key reaction was chemoenzymatic sequential deacetylation to 6′-acetoxy-2′,4″-dihydroxy-4′-methoxychalcone, the in situ-formed precursor for thallium(III) nitrate-mediated oxidative rearrangement.

Flavanone compound as well as preparation method and application thereof

The invention belongs to the technical field of medicines, and particularly relates to a flavanone compound as well as a preparation method and application thereof. Specifically disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The compound shown in the formula (I) can target hURAT1 and/or GLUT9, so that uric acid excretion is promoted, and the effect of reducing uric acid is achieved. The compound can be used for preparing medicines for treating and/or preventing and/or delaying and/or adjunctively treating and/or treating diseases related to hURAT1/GLUT9 activity, and has a good application prospect in preventing or treating diseases (such as gout, gouty arthritis, uric acid kidney stone and the like) related to hyperuricemia.

A Biomimetic Strategy to Access the Silybins: Total Synthesis of (-)-Isosilybin A

(Figure Presented). We report the first asymmetric, total synthesis of (-)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible app