2944-52-7Relevant articles and documents
Synthesis method and application of propofol sodium and intermediate thereof
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Paragraph 0029, (2021/09/22)
The method comprises an intermediate B and an intermediate C, and, the application of the phosphorus propofol sodium prepared by the synthesis method in an animal anesthetic sedative. The phosphorus propofol sodium synthesis method provided by the invention avoids the use of highly toxic reagent chlorobromomethane and is high in safety. The prepared propofol intermediate reaction condition is mild, the operation is simple and convenient, the quality yield is ＞ 97%, and the propofol prodrug synthesized by the synthetic method provided by the invention can generate the same clinical effect as the commercially available propofol emulsion injection.
ALPHAvBETA1 INTEGRIN ANTAGONISTS
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Paragraph 0171; 0285, (2020/01/31)
The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ανβ1 and/or α5β1. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ανβ3, ανβ5, ανβ6, ανβ8, and/or αIIbβ3.
Nuclear receptor ligands and ligand binding domains
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, (2008/06/13)
The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (her
