294673-72-6

Basic information

• Product Name: (2,4-dichloropyrimidin-5-yl)-N-[2-nitro-5-(trifluoromethyl)phenyl]carboxamide
• CAS NO: 294673-72-6
• Molecular Weight: 381.098
• Mol File: 294673-72-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2,4-dichloropyrimidin-5-yl)-N-[2-nitro-5-(trifluoromethyl)phenyl]carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-dichloropyrimidin-5-yl)-N-[2-nitro-5-(trifluoromethyl)phenyl]carboxamide(294673-72-6)
• EPA Substance Registry System: (2,4-dichloropyrimidin-5-yl)-N-[2-nitro-5-(trifluoromethyl)phenyl]carboxamide(294673-72-6)

Safety Data

• Hazardous Substances Data: 294673-72-6(Hazardous Substances Data)

Upstream product

• 402-14-2 2-nitro-5-(trifluoromethyl)aniline 
• 2972-52-3 2,4-dichloropyrimidine-5-carbonyl chloride 

Relevant articles and documents

Synthesis and structure-activity relationship studies of conformationally restricted, analogs of 2-chloro-4-trifluoromethylpyrimidine- 5-[N-(3',5'-bis(trifluoromethyl)phenyl)]carboxamide

2-Chloro-4-trifluoromethylpyrimidine-5-N[(3,5- bis(trifluoromethyl)phenyl] carboxamide (1) was identified as an inhibitor of AP-1 and NF-κB mediated transcriptional activation. In an effort to identify novel compounds that contain less number of trifluoromethyl groups with comparable potency as 1, several conformationally restricted analogs of I were synthesized in which the pyrimidine ring and the aniline ring were connected through a second 'bridge'. The 7-membered sulfur bridged analog was the most potent in this series, and comparable to 1 in activity.