29480-09-9

Basic information

• Product Name: Cyclobutanol, 1-(4-chlorophenyl)-
• CAS NO: 29480-09-9
• Molecular Formula: C10H11ClO
• Molecular Weight: 182.65
• Mol File: 29480-09-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Cyclobutanol, 1-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanol, 1-(4-chlorophenyl)-(29480-09-9)
• EPA Substance Registry System: Cyclobutanol, 1-(4-chlorophenyl)-(29480-09-9)

Safety Data

• Hazardous Substances Data: 29480-09-9(Hazardous Substances Data)

Upstream product

• 106-39-8 bromochlorobenzene 
• 1191-95-3 cyclobutanone 
• 637-87-6 1-Chloro-4-iodobenzene 
• 106-46-7 para-dichlorobenzene 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 22217-78-3 5-(4-chlorophenyl)-3,4-dihydro-2H-pyrrole 
• 50921-39-6 1-(4-chlorophenyl)cyclobutane-1-carboxylic acid 
• 26086-96-4 1,8-bis(4-chlorophenyl)octane-1,8-dione 
• 40877-09-6 4-chloro-1-(4-chlorophenyl)butan-1-one 

Relevant articles and documents

Iron-Catalyzed Ring Expansion of Cyclobutanols for the Synthesis of 1-Pyrrolines by Using MsONH3OTf

The synthesis of 1-pyrrolines from cyclobutanol derivatives and an aminating reagent (MsONH3OTf) has been developed. This one-pot procedure achieves C–N bond/C═N bond formation via ring expansion. A series of 1-pyrroline derivatives are synthes

Terminal Trifluoromethylation of Ketones via Selective C-C Cleavage of Cycloalkanols Enabled by Hypervalent Iodine Reagents

We report the first terminal trifluoromethylation at aryl and alkyl ketones' ?, or more remote sites via the selective C-C bond cleavage of cycloalkanols. The noncovalent interactions between alcohols and hypervalent iodines(III) reagents were disclosed to activate both alcohols and the Togni I reagent in the dual photoredox/copper catalysis for the transformation. This reaction was scalable to the gram-scale synthesis, applicable to the structurally complex steroid trifluoromethylation, and extendable to the pentafluoroethylation.

Manganese-Catalyzed Electrochemical Deconstructive Chlorination of Cycloalkanols via Alkoxy Radicals

A manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols has been developed. This electrochemical method provides access to alkoxy radicals from alcohols and exhibits a broad substrate scope, with various cyclopropanols and cyclobutanols converted into synthetically useful β- and γ-chlorinated ketones (40 examples). Furthermore, the combination of recirculating flow electrochemistry and continuous inline purification was employed to access products on a gram scale.