29551-81-3Relevant articles and documents
Synthesis method of 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate
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Paragraph 0041; 0048-0052, (2019/10/01)
The invention provides a synthesis method of a 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate. The synthesis method comprises the following steps of dissolving o-halogenated aniline in an organic solvent, then adding alkali, then adding an acylating agent, and carrying out an acylation reaction between the o-halogenated aniline and the acylating agent under an alkaline condition to obtaina compound I; carrying out a chlorination reaction between the compound I and a chlorinating agent under a weakly alkaline condition to obtain a compound II; adopting the compound II and magnesium for a reaction in an environment of inert gas to obtain a Grignard reagent intermediate, and carrying out a reaction between the Grignard reagent intermediate and a trifluoroacetic acid derivative to obtain a compound III; carrying out a reaction between the compound III and concentrated hydrochloric acid to obtain the 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate. According to the synthesis method, the reaction condition is mild, the adopted raw materials are easy to obtain, the price is low, the total yield of the prepared target product can reach 80.35%, the purity can reach 99.8%,and the synthesis method is suitable for industrial production.
