29601-98-7Relevant articles and documents
Method for preparing N -benzylhydroxylamine hydrochloride with high yield
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Paragraph 0076; 0078; 0083-0086, (2021/08/25)
The invention discloses a method for preparing N - benzylhydroxylamine hydrochloride in a high yield, which comprises the following steps: S01, taking dibenzylamine as a starting raw material, adding a solvent, a catalyst and dropwise adding first oxidant
Profiling base excision repair glycosylases with synthesized transition state analogs
Chu, Aurea M.,Fettinger, James C.,David, Sheila S.
supporting information; experimental part, p. 4969 - 4972 (2011/10/09)
Two base excision repair glycosylase (BER) transition state (TS) mimics, (3R,4R)-1-benzyl (hydroxymethyl) pyrrolidin-3-ol (1NBn) and (3R,4R)- (hydroxymethyl) pyrrolidin-3-ol (1N), were synthesized using an improved method. Several BER glycosylases that repair oxidized DNA bases, bacterial formamidopyrimdine glycosylase (Fpg), human OG glycosylase (hOGG1) and human Nei-like glycosylase 1 (hNEIL1) exhibit exceptionally high affinity (K d~pM) with DNA duplexes containing the 1NBn and 1N nucleotide. Notably, comparison of the Kd values of both TS mimics relative to an abasic analog (THF) in duplex contexts paired opposite C or A suggest that these DNA repair enzymes use distinctly different mechanisms for damaged base recognition and catalysis despite having overlapping substrate specificities.
One-pot synthesis and hydroxylaminolysis of asymmetrical acyclic nitrones
Coskun, Necdet,Parlar, Aydin
, p. 2445 - 2451 (2007/10/03)
Aromatic aldehydes 1 were reductively aminated to the corresponding secondary amines 2 using NaBH4 in methanol in good yields. Amines 2 were oxidized with H2O2-WO42- regioselectively to nitrones 3, the structures of which were easily determined by reacting them with hydroxylamine hydrochloride as well as by spectral means. The products of hydroxylaminolysis in ether proved to be the corresponding benzaldehyde oximes 4 and benzyl or methyl hydroxylamine hydrochlorides 5. Copyright Taylor & Francis, Inc.