2961-04-8

Basic information

• Product Name: 1,4,5-TRIHYDROXYANTHRAQUINONE
• Synonyms: 1,4,5-TRIHYDROXYANTHRAQUINONE;1,4,8-TRIHYDROXYANTHRAQUINONE;1,4,5-trihydroxy-9,10-anthraquinone;1,4,5-trihydroxyanthracene-9,10-dione
• CAS NO: 2961-04-8
• Molecular Formula: C₁₄H₈O₅
• Molecular Weight: 256.21032
• EINECS: 220-992-0
• Mol File: 2961-04-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 254-256 °C (decomp)
• Boiling Point: 503.4°Cat760mmHg
• Flash Point: 272.3°C
• Appearance: /
• Density: 1.659g/cm³
• Vapor Pressure: 9.35E-11mmHg at 25°C
• Refractive Index: 1.772
• PKA: 6.36±0.20(Predicted)
• CAS DataBase Reference: 1,4,5-TRIHYDROXYANTHRAQUINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,5-TRIHYDROXYANTHRAQUINONE(2961-04-8)
• EPA Substance Registry System: 1,4,5-TRIHYDROXYANTHRAQUINONE(2961-04-8)

Safety Data

• Hazardous Substances Data: 2961-04-8(Hazardous Substances Data)

Usage

Family

Anthraquinone

Type

Naturally occurring organic compound

Color

Red pigment

Natural Sources

Various plants, lichens, and fungi

Industrial Use

Dyeing and coloring in the textile industry

Chemical Structure

Three hydroxyl groups attached to an anthraquinone core

Pharmacological Properties

a. Antioxidant
b. Anti-inflammatory
c. Anticancer effects

Traditional Medicine Uses

a. Laxative
b. Diuretic

InChI:InChI=1/C14H8O5/c15-7-3-1-2-6-10(7)14(19)12-9(17)5-4-8(16)11(12)13(6)18/h1-5,15-17H

Upstream product

• 117-10-2 1,8-dihydroxy-9,10-anthracenedione 
• 1594-64-5 1,4,8-Trichloroanthraquinone 
• 496-64-0 3-hydroxy-2-pyrone 
• 475-38-7 5,8-Dihydroxy-1,4-naphthoquinone 
• 64831-67-0 1,4-dihydroxy-5-methoxy-9,10-anthracenedione 
• 64831-62-5 2-<2,5-Dimethoxy-benzoyl>-6-methoxy-benzoesaeure 
• 75314-06-6 1,4,5-triacetoxy-9,10-anthraquinone 
• 86278-83-3 4-ethylenedioxy-(3-nitromethyl)-pentanal 
• 69043-83-0 1,4-dioxo-1,2,3,4-tetrahydro-5,9,10-trihydroxyanthracene(leuco 1,4,5-trihydroxy-9,10-anthraquinone) 
• 98122-88-4 8,9-dihydroxy-10-chloro-1,4-anthraquinone 
• 98122-61-3 8-methoxy-9-hydroxy-10-chloro-1,4-anthraquinone 
• 78048-08-5 5-hydroxy-1,4-dimethoxyanthraquinone 
• 98122-86-2 7-Hydroxy-2,2-dioxo-1,3-dioxa-2λ⁶-thia-benzo[de]anthracene-8,11-dione 
• 78048-09-6 4,5-dihydroxy-1-methoxyanthraquinone 

Downstream Products

• 81-60-7 1,4,5,8-tetrahydroxy-anthraquinone 
• 476-56-2 islandicin 
• 117-12-4 1,5-dihydroxyanthraquinone 
• 117-10-2 1,8-dihydroxy-9,10-anthracenedione 
• 132000-29-4 5-Deoxy-3-O-benzyl-3-C-methyl-1,2-O-isopropylidene-5-(9',10',-dihydro-1',4',5'-trihydroxy-9',10'-dioxo-2'-anthryl)-α-D-ribofuranose hemihydrate 
• 132000-30-7 (4S)-2-O-Benzyl-2-C-methyl-3-O-formyl-4-(9',10'-dihydro-1',4',5'-trihydroxy-9',10'-dioxo-2-anthryl)-α,β-D-erythro-tetrafuranose 
• 132000-30-7 (4R)-2-O-Benzyl-2-C-methyl-3-O-formyl-4-(9',10'-dihydro-1',4',5'-trihydroxy-9',10'-dioxo-2'-anthryl)-α(β)-D-erythro-tetrafuranose hemihydrate 
• 132000-34-1 (5R)-3-O-Benzyl-3-C-methyl-5-(9',10'-dihydro-1',4',5'-trihydroxy-9',10'-dioxo-2'-anthryl)-α-β-D-ribopyranose 
• 132000-34-1 (5S)-3-O-Benzyl-3-C-methyl-5-(9',10'-dihydro-1',4',5'-trihydroxy-9',10'-dioxo-2-anthryl)-α,β-D-ribopyranose 
• 132024-68-1 (5R)-3-O-benzyl-3-C-methyl-1,2-O-isopropylidene-5-(9',10'-dihydro-1',4',5'-trihydroxy-9',10'-dioxo-2'-anthryl)-α-D-ribofuranose hemihydrate 
• 132000-36-3 (5S)-3-O-Benzyl-3-C-methyl-1,2-O-isopropylidene-5-(9',10'-dihydro-1',4',5'-trihydroxy-9',10'-dioxo-2'-anthryl)-α-D-ribofuranose 

Relevant articles and documents

1,4-Anthraquinonoid dienophiles applicable to synthesis of linear tetracycles

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Novel anthraquinones and process for the preparation and method of use thereof

A process for the preparation of hydroxyl substituted anthraquinones is described. The process couples a phthalic anhydride (substituted or unsubstituted) to benzene ring moiety substituted with at least two hydroxyl groups. Remaining hydroxy groups were converted to methoxy groups in some anthraquinones. The compounds are particularly useful for the treatment of parasitic diseases. Also, a method of treating or preventing malaria, filariasis schistosomiasis and other parasitic diseases using anthraquinones.

Polycyclic Hydroxyquinones. Part 18. Diels-Alder Cycloadditions with Chloronaphthazarins as Model Reactions for Regiospecific Construction of the D ring of Anthracyclinones

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