298-55-5Relevant articles and documents
Efficient synthesis of antihistamines clocinizine and chlorcyclizine
Venkat Narsaiah,Narsimha
, p. 538 - 541 (2012/09/22)
A simple and efficient route has been developed for the synthesis of anti-histamine drugs clocinizine and chlorcyclizine. The common intermediate 1-[(4-chloro phenyl) (phenyl)-methyl]-piperazine (8), is prepared from (4-chlorophenyl) (phenyl)-methanone (5), in three steps with excellent yields. All the reactions proceeded smoothly and the products were also isolated easily. Springer Science+Business Media, LLC 2011.