298709-29-2

Basic information

• Product Name: 2-Cyano-3,5-difluoropyridine
• Synonyms: 3,5-Difluoropicolinitrile;3,5-Difluoropyridine-2-carbonitrile;3,5-DIFLURO-2-CYANOPYRIDINE;2-Pyridinecarbonitrile,3,5-difluoro-(9CI);3,5-DIFLUORO-2-PYRIDINECARBONITRILE;2-Cyano-3,5-difluoropyridine, 3,5-Difluoropicolinonitrile;2-Cyano-3,5-difluorpyridine;3,5-difluoronicotinonitrile
• CAS NO: 298709-29-2
• Molecular Formula: C₆H₂F₂N₂
• Molecular Weight: 140.09
• EINECS: -0
• Product Categories: HALIDE;PYRIDINE;NITRILE;Pyridine series;Pyridines;API intermediates;Fluorine series
• Mol File: 298709-29-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 32-34°C
• Boiling Point: 187.8 °C at 760 mmHg
• Flash Point: 90℃
• Appearance: /
• Density: 1.36 g/cm³
• Vapor Pressure: 0.618mmHg at 25°C
• Refractive Index: 1.483
• Storage Temp.: 0-10°C
• Solubility: soluble in Methanol
• PKA: -5.16±0.20(Predicted)
• CAS DataBase Reference: 2-Cyano-3,5-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-3,5-difluoropyridine(298709-29-2)
• EPA Substance Registry System: 2-Cyano-3,5-difluoropyridine(298709-29-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 298709-29-2(Hazardous Substances Data)

Usage

Description

2-Cyano-3,5-difluoropyridine is an organic compound characterized by its white to orange to green powder or crystalline appearance. It is a significant reactant in the pharmaceutical industry due to its ability to be used in the preparation of potent and selective inhibitors.

Uses

Used in Pharmaceutical Industry:
2-Cyano-3,5-difluoropyridine is used as a reactant for the preparation of DPP-4 inhibitors, which are potent and selective. These inhibitors are known for their attractive pharmacokinetic profile and are utilized as antidiabetics, helping to manage and treat diabetes more effectively.
2-Cyano-3,5-difluoropyridine's versatility in the preparation of these inhibitors makes it a valuable asset in the development of new medications for diabetes management. Its unique properties allow for the creation of drugs that can better regulate blood sugar levels, offering improved treatment options for patients with diabetes.

InChI:InChI=1/C6H2F2N2/c7-4-1-5(8)6(2-9)10-3-4/h1,3H

Upstream product

• 85331-33-5 2-Cyano-3,5-dichloropyridine 

Downstream Products

• 955011-66-2 5-fluoro-3-(2-fluoro-4-iodo-phenylamino)-pyridine-2-carbonitrile 
• 780801-58-3 3,5-difluoropicolinaldehyde 
• 864543-75-9 (3,5-difluoropyridin-2-yl)(2-methoxyphenyl)methanone 
• 1075756-90-9 1-(3,5-difluoropyridin-2-yl)ethan-1-one 
• 1204298-48-5 1-(3,5-difluoropyridin-2-yl)methanamine hydrochloride 
• 1204298-48-5 1-(3,5-difluoropyridin-2-yl)methanamine dihydrochloride 
• 745784-04-7 3,5-difluoropyridine-2-carboxylic acid 
• 1073973-77-9 2-cyano-5-fluoro-3-(4-trans-hydroxycyclohexylamino)pyridine 
• 1190423-45-0 3-(4-trans-hydroxycyclohexylamino)-5-[4-quinolin-3-yl-9H-carbazol-9-yl]pyridine-2-carboxamide 
• 1190424-49-7 3-(4-trans-hydroxycyclohex-1-ylamino)-5-[4-(quinolin-3-yl)-9H-carbazol-9-yl]pyridine-2-carbonitrile 
• 1190424-32-8 2-cyano-5-fluoro-3-(1,2,2,6,6-pentamethylpiperidin-4-yl)aminopyridine 
• 1393456-51-3 3,5-bis(4-methoxybenzyloxy)pyridine-2-carbonitrile 

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