29875-07-8 Usage
General Description
4-Methylbenzylmagnesium chloride is a chemical compound used as a reagent in organic synthesis. It is commonly employed as a source of the 4-methylbenzyl nucleophile in Grignard reactions, which are important in the formation of carbon-carbon bonds in organic compounds. This reagent is a powerful tool in the synthesis of various pharmaceuticals, agrochemicals, and fine chemicals. It is typically prepared in situ by reacting 4-methylbenzyl chloride with magnesium metal in anhydrous diethyl ether, and then used immediately in the desired reaction. 4-METHYLBENZYLMAGNESIUM CHLORIDE is highly reactive and requires careful handling and storage under inert atmosphere due to its sensitivity to moisture and air.
Check Digit Verification of cas no
The CAS Registry Mumber 29875-07-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,8,7 and 5 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 29875-07:
(7*2)+(6*9)+(5*8)+(4*7)+(3*5)+(2*0)+(1*7)=158
158 % 10 = 8
So 29875-07-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H9.ClH.Mg/c1-7-3-5-8(2)6-4-7;;/h3-6H,1H2,2H3;1H;/q-1;;+2/p-1
29875-07-8Relevant articles and documents
Syntheses of 7-Substituted Anthra[2,3- b]thiophene Derivatives and Naphtho[2,3- b:6,7- b']dithiophene
Al-Jumaili, Mustafa A.,Woodward, Simon
, p. 11437 - 11445 (2018/09/06)
7-R-Anthra[2,3-b]thiophene derivatives (1, R = H, Me, i-Pr, or MeO) are prepared in three steps (in average overall yield >50%) starting from (E)-4-RC6H4CH2(HOCH2)C=CI(CH2OH). The latter are commercial or readily prepared from 2-butyne-1,4-diol and ArCH2Cl (both costing 1 cent/mmol) at 10 g scales. These allow for the selective formation of (otherwise unattainable) higher solubility 7-derivatives. Similar methods allow for the preparation of naphtho[2,3-b:6,7-b']dithiophene 2 using equally low-cost starting materials.
