299912-61-1 Usage
Description
4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)is a complex organic compound with a quinazolinamine core structure, featuring a 3-ethylphenyl group attached to the nitrogen atom and two 2-methoxyethoxy groups at the 6th and 7th positions. 4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)is characterized by its unique molecular structure and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)is used as an impurity in the production of Tetrahydro Erlotinib, which is an impurity of Erlotinib (E625000, HCl). Erlotinib is a selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and an antineoplastic agent. 4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)plays a role in the development and manufacturing process of these cancer-fighting drugs, contributing to their overall effectiveness and safety.
Used in Research and Development:
In addition to its pharmaceutical applications, 4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)may also be utilized in research and development for the discovery of new drugs and therapies. Its unique chemical properties make it a valuable compound for studying interactions with various biological targets and exploring its potential as a therapeutic agent in different medical fields.
Used in Chemical Synthesis:
4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)can be employed as a building block or intermediate in the synthesis of other complex organic molecules, particularly those with potential applications in the pharmaceutical, agrochemical, or materials science industries. Its versatile structure allows for further functionalization and modification to create new compounds with tailored properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 299912-61-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,9,9,1 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 299912-61:
(8*2)+(7*9)+(6*9)+(5*9)+(4*1)+(3*2)+(2*6)+(1*1)=201
201 % 10 = 1
So 299912-61-1 is a valid CAS Registry Number.
299912-61-1Relevant articles and documents
Identification of ketene-reactive intermediate of erlotinib possibly responsible for inactivation of P450 enzymes
Zhao, Huimin,Li, Siyuan,Yang, Zixin,Peng, Ying,Chen, Xiaohui,Zheng, Jiang
, p. 442 - 450 (2018/03/22)
Erlotinib (ELT), a tyrosine kinase inhibitor, is widely used for the treatment of nonsmall cell lung cancer in clinic. Unfortunately, severe drug-induced liver injury and other adverse effects occurred during the treatment. Meanwhile, ELT has been reported to be a mechanism-based inactivator of cytochrome P450(CYPs) 3A4 and 3A5. The objectives of this study were to identify ketene intermediate of ELT and investigate the association of the acetylenic bioactivation with the enzyme inactivation caused by ELT. A ketene intermediate was detected in human microsomal incubations of ELT, using 4-bromobenzylamine as a trapping agent. CYPs 3A4 and 3A5 mainly contributedtothe bioactivation of ELT. Microsomal incubation study showed that the ketene intermediate covalently modified the enzyme protein at lysine residues and destroyed the structure of heme. The vinyl and ethyl analogs of ELT showed minor enzyme inhibitory effect (less than 20%), whereas ELT inactivated more than 60% of the enzyme. The present study providedanovel bioactivation pathway of ELT and facilitated the understanding of the mechanisms of ELT-induced mechanism-based enzyme inactivation and liver injury.
