299912-77-9

Basic information

• Product Name: 6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one
• Synonyms: 6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one;3(2H)-Benzofuranone, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
• CAS NO: 299912-77-9
• Molecular Formula: C₁₄H₂₀O₃Si
• Molecular Weight: 264.3923
• Mol File: 299912-77-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one(299912-77-9)
• EPA Substance Registry System: 6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one(299912-77-9)

Safety Data

• Hazardous Substances Data: 299912-77-9(Hazardous Substances Data)

Usage

General Description

6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one is a chemical compound with a structure containing a benzofuran ring with a tert-butyldimethylsilyl group attached to an oxygen atom. 6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one is often used in organic synthesis as a protecting group for alcohols, allowing for selective manipulation of reactive functional groups in a molecule. It is also used in the preparation of various pharmaceuticals and bioactive compounds. Additionally, this compound has potential applications in materials science and as a reagent in organic chemistry reactions. Overall, 6-((tert-butyldimethylsilyl)oxy)benzofuran-3(2H)-one is a versatile and important compound in the field of organic chemistry with a range of uses and potential applications.

Upstream product

• 6272-26-0 6-hydroxybenzofuran-3-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 288-32-4 1H-imidazole 

Downstream Products

• 13196-11-7 6-hydroxybenzofuran 
• 123297-88-1 benzofuran-6-carboxaldehyde 
• 227752-25-2 trifluoromethanesulfonic acid benzofuran-6-yl ester 
• 204452-96-0 (S)-3-Benzofuran-6-yl-3-[benzyl-((R)-1-phenyl-ethyl)-amino]-propionic acid ethyl ester 
• 77095-51-3 benzofuran-6-carboxylic acid 
• 588703-29-1 methyl benzofuran-6-carboxylate 
• 1194550-67-8 ((S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-methylsulfonyl)phenyl)propanoate 
• 1025967-78-5 (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid 
• 69120-06-5 moracin C 
• 936006-11-0 2-[3',5'-dihydroxy-4'-(3-methlbut-1-enyl)phenyl]-6-hydroxybenzofuran 
• 69120-07-6 moracin D 
• 56317-21-6 moracin M 
• 218444-38-3 2-(3,5-dimethoxyphenyl)-6-(tert-butyl-dimethylsilanyloxy)benzofuran 
• 218444-39-4 2-[[3,5-dimethoxy-4-(3-methyl-2-butenyl)]phenyl]-6-(tert-butyldimethylsilanyloxy)benzofuran 

Relevant articles and documents

PD-1/PD-L1 small-molecule inhibitor and preparation method and application thereof

The invention discloses a PD-1/PD-L1 small-molecule inhibitor and a preparation method and application thereof. Specifically, the invention discloses a compound with the structure shown in the formulaL, a stereoisomer or a tautomer thereof, or pharmaceutically acceptable salts or hydrates or solvates thereof, and please see the specification for specific definitions. The compound has excellent effects for restraining PD-1/PD-L1. Please see the specification for the formula.

LFA-1 INHIBITOR AND POLYMORPH THEREOF

Methods of preparation and purification of a compound, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA -1 mediated diseases are also disclosed.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.