300-30-1

Basic information

• Product Name: DL-THYROXINE
• Synonyms: DL-THYROXINE;DL-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]ALANINE;DL-3,3',5,5'-TETRAIODOTHYRONINE;DL-3,5-DIIODO-4-(3',5'-DIIODO-4'-HYDROPHENOXY)-PHENYLALANINE;3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]ALANINE;3,3',5,5'-TETRAIODO-DL-THYRONINE;2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID;O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-DL-tyrosine
• CAS NO: 300-30-1
• Molecular Formula: C₁₅H₁₁I₄NO₄
• Molecular Weight: 776.87
• EINECS: 206-088-9
• Product Categories: Amino Acids;Biochemistry;Biological-modified Amino Acids
• Mol File: 300-30-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 211 °C (decomp)
• Boiling Point: 576.306 °C at 760 mmHg
• Flash Point: 302.339 °C
• Appearance: /
• Density: 2.635 g/cm³
• PKA: 2.12±0.30(Predicted)
• Merck: 9415
• CAS DataBase Reference: DL-THYROXINE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-THYROXINE(300-30-1)
• EPA Substance Registry System: DL-THYROXINE(300-30-1)

Safety Data

• Hazardous Substances Data: 300-30-1(Hazardous Substances Data)

Usage

Description

DL-THYROXINE, also known as an iodothyronine compound, is a significant hormone derived from the thyroid gland. It possesses a unique structure with iodo substituents at the 3-, 3'-, 5-, and 5'-positions, which play a crucial role in its biological functions. DL-THYROXINE is essential for various physiological processes, including metabolism, growth, and development.

Uses

Used in Pharmaceutical Industry:
DL-THYROXINE is used as a therapeutic agent for treating various thyroid-related disorders, such as hypothyroidism and goiter. It helps in regulating the body's metabolism and maintaining a healthy energy balance.
Used in Diagnostic Applications:
DL-THYROXINE is employed as a diagnostic tool in the assessment of thyroid function. It aids in the detection and monitoring of thyroid-related conditions, enabling healthcare professionals to make informed decisions regarding treatment plans.
Used in Research and Development:
DL-THYROXINE serves as an essential compound in scientific research, particularly in the fields of endocrinology and molecular biology. It is used to study the effects of thyroid hormones on cellular processes and to develop new therapeutic strategies for thyroid-related diseases.

InChI:InChI=1/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)

Upstream product

• 534-51-0 3,5-diiodo-DL-thyronine 

Downstream Products

• 86154-70-3 3,5,3',5'-tetraiodo-thyronine methyl ester; hydrochloride 
• 24486-40-6 L-thyroxine 
• 24486-40-6 (D)-thyroxine 
• 63238-74-4 2,2,3,3,4,4,4-Heptafluoro-butyric acid 4-{4-[2-(2,2,3,3,4,4,4-heptafluoro-butyrylamino)-2-methoxycarbonyl-ethyl]-2,6-diiodo-phenoxy}-2,6-diiodo-phenyl ester 
• 14000-22-7 3-{4-[3,5-Diiodo-4-(2,2,2-trifluoro-acetoxy)-phenoxy]-3,5-diiodo-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester 
• 80527-51-1 2,2,3,3,3-Pentafluoro-propionic acid 4-{2,6-diiodo-4-[2-methoxycarbonyl-2-(2,2,3,3,3-pentafluoro-propionylamino)-ethyl]-phenoxy}-2,6-diiodo-phenyl ester 
• 556-02-5 ?Tyr 
• 14707-93-8 {Cu(HOC₆H₂I₂OC₆H₂I₂CH₂CH(NH₂)COO)2} 
• 51-48-9 L-thyroxine 
• 51-49-0 dextrothyroxine 
• 88404-22-2 2-[(tert-butoxycarbonyl)amino]-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid 
• 6893-02-3 triiodothyronine 

Relevant articles and documents

BIOTINYLATED THYROXINE

A means for conveniently and accurately measuring thyroxine or thyronine present in the blood or the like is provided: a compound represented by general formula (I) below: wherein L represents a linear or branched-chain linker having 5 to 50 total atoms; X represents one or more thyroxines, thyronines, or residues of derivatives thereof, bound to the main chain and/or side chain of the linker represented by L, a conjugate in the form of the above compound bonded to an avidin protein, and an aqueous dispersion including a microparticles the surface of which is modified with the above conjugate.

Therapeutic methods utilizing naturally derived bio-active complexes and delivery systems therefor

Methods are disclosed for correcting biological information transfer in a patient in need of such therapy which comprise administration to a patient of a composition comprising a therapeutically effective amount of a biocomplex comprising at least one bioactive agent from each of the three informational blocks of biological information transfer, each agent being present in an amount sufficient to correct the biological information transfer of the patient under treatment and resulting in the resumption of normal cell metabolism, said amount being less than the buffering amount of said agent; together with a carrier therefor.

Model reactions for the biosynthesis of thyroxine. XI. The nature of a free radical formed in the autoxidation of 4-hydroxy-3,5-diiodophenylpyruvic acid.

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