30058-27-6

Basic information

• Product Name: 4-(4,5-dimethoxy-2-nitro-phenyl)morpholine
• Synonyms: 4-(4,5-dimethoxy-2-nitro-phenyl)morpholine
• CAS NO: 30058-27-6
• Molecular Weight: 268.269
• Mol File: 30058-27-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4,5-dimethoxy-2-nitro-phenyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4,5-dimethoxy-2-nitro-phenyl)morpholine(30058-27-6)
• EPA Substance Registry System: 4-(4,5-dimethoxy-2-nitro-phenyl)morpholine(30058-27-6)

Safety Data

• Hazardous Substances Data: 30058-27-6(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 3395-03-7 4,5-dimethoxy-1,2-dinitrobenzene 
• 51072-66-3 1-bromo-4,5-dimethoxy-2-nitro-benzene 
• 1444018-10-3 potassium 4,5-dimethoxy-2-nitrobenzoate 

Downstream Products

• 30235-82-6 N,N-bis-(2-diethylamino-ethyl)-4,5-dimethoxy-2-morpholin-4-yl-aniline 
• 30058-28-7 4,5-dimethoxy-2-(morpholin-4-yl)aniline 

Relevant articles and documents

Decarboxylative ipso Amination of Activated Benzoic Acids

In the presence of a bimetallic Pd/Cu system with 1,10-phenanthroline as the ligand and either air or N-methylmorpholine N-oxide as the oxidant, electron-deficient benzoic acids undergo oxidative decarboxylative coupling with unprotected amines. This operationally simple aniline synthesis is widely applicable with respect to the amine and gives good yields, even on multigram scale. The orthogonality of this reaction to other Pd-catalyzed cross-couplings allows the concise synthesis of multisubstituted arenes by sequential C?C, C?Cl, and C?N functionalizations. Mechanistic investigations suggest the intermediacy of a hypervalent Pd species.