300657-41-4Relevant articles and documents
Green method for high-selectivity synthesis of chalcone compounds
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Paragraph 0079-0082, (2021/10/02)
Under the condition of air, the water-soluble inorganic weak base is used as a catalyst to catalyze the hydrogen transfer reaction of the propargyl alcohol compound, so that the green synthesis of the high-trans selective chalcone compound is realized. Reaction temperature: 80 - 120 °C and reaction time 12 - 48 hours. To the technical scheme, any transition metal catalyst and ligand do not need to be used, inert gas protection is not needed, no other byproducts are generated, the atom economy 100%, green and environment friendliness are avoided, and the product is a high-selectivity (E)-type product. The reaction conditions are relatively low in requirement. Compared with the prior art, the alkali catalyst is obvious in advantages, and has a certain application prospect in the fields of organic synthesis, biochemistry, medicine and the like.
Stereoselective construction of novel biaryl bridged seven-membered ring scaffolds via intramolecular [3 + 2] cycloaddition reactions
Butt, Hafiza Marium,Wei, Shiqiang,Wang, Yue,Qu, Jingping,Wang, Baomin
supporting information, (2021/11/24)
A novel approach to biaryl bridged seven-membered carbocyclic scaffolds was developed by means of an intramolecular [3 + 2] cycloaddition process of in situ formed azomethine ylides from 2-cinnamoyl-2'-formyl biphenyl and diethyl aminomalonate hydrochlori
Beyond the Corey–Chaykovsky Reaction: Synthesis of Unusual Cyclopropanoids via Desymmetrization and Thereof
Patel, Kaushalendra,Mishra, Uttam K.,Mukhopadhyay, Dipto,Ramasastry
supporting information, p. 4568 - 4571 (2019/11/03)
Desymmetrization-based protocols for the synthesis of highly functionalized indeno-spirocyclopropanes and cyclopropa-fused indanes have been established through unexpected reactions triggered by the Corey–Chaykovsky reagent. These structures were further elaborated in one step to privileged scaffolds such as fluorenones, indenones, and naphthaphenones. For instance, an acid-catalyzed transformation of indeno-spirocyclopropanes provided fluorenones via a homo-Nazarov-type cyclization, and naphthaphenones were obtained via an acid-catalyzed cyclopropane ring-opening/retro-Michael sequence.