300854-35-7Relevant articles and documents
New analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, with anti-tumor activity
Murakami, Nobutoshi,Tamura, Satoru,Koyama, Kouhei,Sugimoto, Masanori,Maekawa, Ryuji,Kobayashi, Motomasa
, p. 2597 - 2601 (2004)
Two analogues possessing steric hindered substituents on C-15 of arenastatin A (1), a potent cytotoxic spongean depsipeptide, were synthesized and shown to enhance stability in mouse serum. Notably, 15-tert-butylanalogue (6) with higher cytotoxicity exhib