301221-56-7Relevant articles and documents
Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques
Di Lello, Paola,Pastor, Richard,Murray, Jeremy M.,Blake, Robert A.,Cohen, Frederick,Crawford, Terry D.,Drobnick, Joy,Drummond, Jason,Kategaya, Lorna,Kleinheinz, Tracy,Maurer, Till,Rougé, Lionel,Zhao, Xianrui,Wertz, Ingrid,Ndubaku, Chudi,Tsui, Vickie
, p. 10056 - 10070 (2018/01/10)
USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53, and for this reason it has gained increasing attention as a potential oncology target for small molecule inhibitors. Herein we describe the biophysical, biochemical, and comput
4-ALKYL SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-a]PYRAZIN-1(2H)-ONE DERIVATIVES AS KINASES INHIBITORS
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Page/Page column 64, (2013/04/24)
The present invention relates to 4-alkyl substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them
INHIBITORS OF SPHINGOSINE KINASE
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Page/Page column 60, (2012/10/08)
The present invention relates to compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12,