301225-58-1

Basic information

• Product Name: 1-Boc-4-Propylaminopiperidine
• Synonyms: 4-PROPYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-PROPYLAMINO-1-BOC-PIPERIDINE;4-Propylamino-1-Boc;1-BOC-4-PROPYLAMINOPIPERIDINE;tert-butyl 4-(propylamino)piperidine-1-carboxylate;N-Boc-4-propylaminopiperidine
• CAS NO: 301225-58-1
• Molecular Formula: C₁₃H₂₆N₂O₂
• Molecular Weight: 242.36
• Mol File: 301225-58-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 322.6°C at 760 mmHg
• Flash Point: 148.9°C
• Appearance: /
• Density: 0.99g/cm³
• Vapor Pressure: 0.000276mmHg at 25°C
• Refractive Index: 1.484
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.25±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-4-Propylaminopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-Propylaminopiperidine(301225-58-1)
• EPA Substance Registry System: 1-Boc-4-Propylaminopiperidine(301225-58-1)

Safety Data

• Hazardous Substances Data: 301225-58-1(Hazardous Substances Data)

Usage

General Description

1-Boc-4-Propylaminopiperidine is a chemical compound that belongs to the family of piperidines and is commonly used in medicinal chemistry and pharmaceutical research. It is a derivative of piperidine with a butyl substituent at the fourth position and a Boc (tert-butoxycarbonyl) protecting group attached to the amino group. 1-Boc-4-Propylaminopiperidine is used as a building block in the synthesis of various pharmaceuticals and bioactive compounds, particularly in the development of potential drugs for the treatment of neurological and psychiatric disorders. Its molecular structure and properties make it a valuable tool in the study and development of novel therapeutic agents, and it is widely utilized in the pharmaceutical industry for drug discovery and development.

InChI:InChI=1/C13H26N2O2/c1-5-8-14-11-6-9-15(10-7-11)12(16)17-13(2,3)4/h11,14H,5-10H2,1-4H3

Upstream product

• 107-10-8 propylamine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Relevant articles and documents

SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES

The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

INHIBITORS OF MONOAMINE UPTAKE

N,N-disubstituted 4-amino-piperidines of the general Formula (I) are inhibitors of the uptake of serotonin and/or norepinephrine and/or dopamine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: Synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N- (benzyloxycarbonyl)amino)piperidin-1-yl)butanes

(2S)-2-(3-Chlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[spiro (2,3-dihydrobenzthiophene-3,4′-piperidin-1′-yl)]butane S-oxide (1b) has been identified as a potent CCR5 antagonist having an IC50 = 10 nM. Herein, structure-activity relationship studies of non-spiro piperidines are described, which led to the discovery of 4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidine derivatives (3-5) as potent CCR5 antagonists.