30129-18-1

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)CYCLOHEXANOL
• Synonyms: 4-(TRIFLUOROMETHYL)CYCLOHEXAN-1-OL;4-(TRIFLUOROMETHYL)CYCLOHEXANOL;4-(TRIFLUOROMETHYL)CYCLOHEXANOL, CIS/TRANS;4-(TRIFLUOROMETHYL)CYCLOHEXANOL (CIS/TRANS MIXTURE);4-(Trifluoromethyl)cyclohexanol (mixture of cis-and trans-);4-(Trifluoromethyl)cyclohexanol (cis- and trans- mixture);1-Hydroxy-4-(trifluoromethyl)cyclohexane;4-(Trifluoromethyl)cyclohexanol (cis- and trans- mixture)
• CAS NO: 30129-18-1
• Molecular Formula: C₇H₁₁F₃O
• Molecular Weight: 168.16
• Product Categories: Ring Systems
• Mol File: 30129-18-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 78 °C
• Flash Point: 69.158 °C
• Appearance: /
• Density: 1.232 g/cm³
• Refractive Index: 1.4070 to 1.4110
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 14.88±0.40(Predicted)
• Water Solubility: Sparingly soluble in water.(0.26 g/L) (25°C),
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)CYCLOHEXANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)CYCLOHEXANOL(30129-18-1)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)CYCLOHEXANOL(30129-18-1)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36
• RIDADR: 1993
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 30129-18-1(Hazardous Substances Data)

Usage

Description

4-(TRIFLUOROMETHYL)CYCLOHEXANOL is an organic compound with the chemical formula C7H11F3O. It features a cyclohexanol ring with a trifluoromethyl group attached at the 4-position. 4-(TRIFLUOROMETHYL)CYCLOHEXANOL is known for its unique chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
4-(TRIFLUOROMETHYL)CYCLOHEXANOL is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its unique structure allows it to be a key component in the development of new pharmaceutical compounds.
Used in Benzoylthiophenes Research:
In the field of benzoylthiophenes, 4-(TRIFLUOROMETHYL)CYCLOHEXANOL is utilized as an allosteric enhancer (AE) of agonist activity at the A1 adenosine receptor. This application highlights its potential role in modulating receptor activity and contributing to the development of new therapeutic agents targeting the A1 adenosine receptor.

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 343217-50-5 Trifluoro-acetic acid 4-trifluoromethyl-cyclohexyl ester 
• 401-75-2 trifluoromethylcyclohexane 
• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 

Downstream Products

• 30129-20-5 Trifluormethylcyclohexylbromid 
• 75091-99-5 4-(trifluoromethyl)cyclohexan-1-one 
• 75091-95-1 3,5-Dinitro-benzoic acid 4-trifluoromethyl-cyclohexyl ester 
• 75091-96-2 3,5-Dinitro-benzoic acid 4-trifluoromethyl-cyclohexyl ester 
• 75092-01-2 4-trifluoromethylcyclohexanone oxime 
• 30129-21-6 7,7,7-Trifluormenthan-8-ol 
• 133261-24-2 trans-4-trifluoromethylcyclohexyl trans-4-pentylcyclohexanecarboxylate 
• 1225357-08-3 2-bromo-6-(4-trifluoromethyl-cyclohexyloxy)-naphthalene 
• 1225350-98-0 tert-butyl 2,2-dimethyl-5-(5-(trifluoromethyl)-6-(4-(trifluoromethyl)cyclohexyloxy)naphthalen-2-yl)-1,3-dioxan-5-ylcarbamate 
• 1351094-40-0 N-methyl-3-nitro-4-{[4-(trifluoromethyl)cyclohexyl]oxy}benzenesuIfonamide 
• 1355615-80-3 C₂₀H₂₆F₃N₅O₄ 
• 1372626-69-1 C₁₄H₁₆F₃N₅O 
• 1372626-70-4 C₁₄H₁₆F₃N₅O 
• 1400916-98-4 C₁₅H₉F₆N₃O₃ 

Relevant articles and documents

Accessing Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and Saturated Heterocycles: Preferential Hydrogen Addition to the Substitution Sites for Dearomatization

Reported here is a straightforward process in which a cyclic (alkyl)(amino)carbene/Rh catalyst system facilitates the preferential addition of hydrogen to the substitution sites of difluoromethylated and trifluoromethylated arenes and heteroarenes, leading to dearomative reduction. This strategy enables the diastereoselective synthesis of cis-difluoromethylated and cis-trifluoromethylated cycloalkanes and saturated heterocycles, and even allows formation of all-cis multi-trifluoromethylated cyclic products with a defined equatorial orientation of the di- and trifluoromethyl groups. Deuterium-labeling studies indicate that hydrogen preferentially attacks the substitution sites of planar arenes, resulting in dearomatization, possibly with heterogeneous Rh as the reactive species, followed by either reversible or irreversible hydrogen addition to the nonsubstitution sites.

Method for synthesizing cis-trifluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation

The invention discloses a method for synthesizing cis-trifluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation. The method is characterized in that trifluoromethylaromatic hydrocarbons or trifluoromethyl heterocyclic compounds ar

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates to a compound of the following formula 1, pharmaceutically acceptable salt and isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.