30159-70-7 Usage
Synthesis
3-(hydroxymethyl)naphthalen-2-ol is prepared by reacting;Methyl 3-hydroxy-2-naphthoate with;sodium borohydride in;methanol.Methyl 3-hydroxy-2-naphthoate (100 mg, 0.49 mmol) was dissolved in methanol (7.0 ml) with stirring in a round bottom flask. Sodium borohydride (185 mg, 4.90 mmol) was then added in carefully into the reaction mixture in two portions with an interval time of 3 hours between them and left to react overnight. The resultant mixture was quenched with addition of water followed by extraction with ethyl acetate (3×10 ml). The organic extracts were collected, dried with magnesium sulphate and concentrated in vacuo to give the colourless powder title compound as a colourless powder (82 mg, 96%): mp: 193 – 195 ℃ (Lit.: 186 – 188 ℃);vmax/cm-1 3379 br. m (O-H), 2844 w (aro. C-H), 1500 s (aro. C=C); δH (300 MHz; DMSO-d6) 9.82 (1H, br. s., OH), 7.80 (1H, s, C(1)H), 7.76 (1H, d, J 8.1, C(5)H or C(8)H), 7.64 (1H, d, J 8.1, C(5)H or C(8)H), 7.33 (1H, ~t, J 7.5, C(6)H or C(7)H), 7.23 (1H, ~t, J 7.5, C(6)H or C(7)H), 7.09 (1H, s, C(4)H), 5.17 (1H, br. s., OH), 4.63 (2H, br. s., C(9)H2); δC (75 MHz; DMSO-d6) 153.1 (Ar-C), 133.3 (Ar-C), 131.8 (Ar-C) 127.7 (Ar-C), 127.3 (Ar-CH), 125.5 (Ar-CH), 125.4 (Ar-CH), 125.3 (Ar-CH), 122.6 (Ar-CH), 107.9 (Ar-CH), 58.6 (C(9)H2); m/z (-ES) 173 (100%, [MH]-), 174 (12%, [M]-).
Check Digit Verification of cas no
The CAS Registry Mumber 30159-70-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,1,5 and 9 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 30159-70:
(7*3)+(6*0)+(5*1)+(4*5)+(3*9)+(2*7)+(1*0)=87
87 % 10 = 7
So 30159-70-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H10O2/c12-7-10-5-8-3-1-2-4-9(8)6-11(10)13/h1-6,12-13H,7H2
30159-70-7Relevant articles and documents
Development of Photoactivatable Nitroxyl (HNO) Donors Incorporating the (3-Hydroxy-2-naphthalenyl)methyl Phototrigger
Zhou, Yang,Cink, Ruth B.,Fejedelem, Zachary A.,Cather Simpson,Seed, Alexander J.,Sampson, Paul,Brasch, Nicola E.
, p. 1745 - 1755 (2018/04/17)
A new family of photoactivatable HNO donors of general structure RSO2NHO-PT [where PT represents the (3-hydroxy-2-naphthalenyl)methyl (3,2-HMN) phototrigger] has been developed, which rapidly releases HNO. Photogeneration of HNO was demonstrated using the vitamin B12 derivative aquacobalamin as a trapping agent. The amount of sulfonate RSO2– produced was essentially the same as the amount of HNO released upon photolysis, providing a convenient method to indirectly quantify HNO release. Two competing pathways were also observed; a pathway involving O–N bond cleavage leading to release of a sulfonamide, and a pathway resulting in release of the parent Nhydroxysulfonamide RSO2NHOH (for HNO donors with Me- and Ph-containing leaving groups only). Up to approximately 70 % of the HNO-generating pathway was observed with the CF3-containing leaving group, with HNO generation favored for small percentages of aqueous buffer in the acetonitrile/pH 7.00 phosphate buffer solvent mixture. Characterization of the photoproducts obtained from steady-state irradiation by NMR spectroscopy showed that the desired HNO-generating pathway was less favored for HNO donors with Me- and Ph-containing leaving groups compared to the CF3-containing leaving group, suggesting that the excellent CF3-containing leaving group promotes HNO generation.
