301672-80-0Relevant articles and documents
Discovery of potent and selective adamantane-based small-molecule P2X 7 receptor antagonists/interleukin-1β inhibitors
Furber, Mark,Alcaraz, Lilian,Bent, Janice E.,Beyerbach, Armin,Bowers, Keith,Braddock, Martin,Caffrey, Moya V.,Cladingboel, David,Collington, John,Donald, David K.,Fagura, Malbinder,Ince, Frank,Kinchin, Elizabeth C.,Laurent, Celine,Lawson, Mandy,Luker, Timothy J.,Mortimore, Michael M. P.,Pimm, Austen D.,Riley, Robert J.,Roberts, Nicola,Robertson, Mark,Theaker, Jill,Thorne, Philip V.,Weaver, Richard,Webborn, Peter,Willis, Paul
, p. 5882 - 5885 (2008/03/30)
A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of t