30225-80-0Relevant articles and documents
Antimicrobial agent isolated from Coptidis rhizome extract incubated with Rhodococcus sp. strain BD7100
Ishikawa, Kazuki,Takahashi, Kazunori,Hosoi, Syun,Takeda, Hisashi,Yoshida, Hinaka,Wakana, Daigo,Tsubuki, Masayoshi,Sato, Fumihiko,Tojo, Motoaki,Hosoe, Tomoo
, p. 71 - 78 (2019)
Coptidis rhizome (CR) is a widely used herbal medicine that contains protoberberine-type alkaloids. CR extract exhibits various pharmacologic activities. A previous study reported the isolation of Rhodococcus sp. strain BD7100 as a berberine (BBR)-utilizing bacterium, and the BBR-degradation pathway has been investigated. When we incubated strain BD7100 cells with CR extract, the number of viable cells declined with the degradation of components in the CR extract, and the culture broth exhibited antibacterial activity against strain BD7100. These results suggest that CR extract cultured in the presence of strain BD7100 contains one or more antibacterial agents. In this study, we isolated coptirhoquinone A (1) from CR extract incubated with strain BD7100 in Luria–Bertani (LB) medium, and the structure was elucidated using NMR and MS analysis. We also report the total synthesis and antimicrobial activities of 1 against bacteria, fungi, and Pythium sp.
Steric control of site selectivity in the Pd-catalyzed C-H acetoxylation of simple arenes
Cook, Amanda K.,Emmert, Marion H.,Sanford, Melanie S.
supporting information, p. 5428 - 5431 (2013/11/19)
This report describes the use of an oxidant and a ligand to control site selectivity in the Pd(OAc)2-catalyzed C-H acetoxylation of simple arenes. The use of MesI(OAc)2 as the terminal oxidant in combination with acridine as the ligand results in primarily sterically controlled selectivity. In contrast, with Pd(OAc)2 as the catalyst and PhI(OAc)2 as the oxidant, electronic effects dominate the selectivity of arene C-H acetoxylation.
