302957-85-3

Basic information

• Product Name: Carbamic acid, [4-(trifluoromethyl)-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl] -, 1,1-dimethylethyl ester
• CAS NO: 302957-85-3
• Molecular Formula: C19H22F3N3O3S
• Molecular Weight: 429.463
• Mol File: 302957-85-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [4-(trifluoromethyl)-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl] -, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [4-(trifluoromethyl)-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl] -, 1,1-dimethylethyl ester(302957-85-3)
• EPA Substance Registry System: Carbamic acid, [4-(trifluoromethyl)-5-[[(2,4,6-trimethylphenyl)amino]carbonyl]-2-thiazolyl] -, 1,1-dimethylethyl ester(302957-85-3)

Safety Data

• Hazardous Substances Data: 302957-85-3(Hazardous Substances Data)

Upstream product

• 88-05-1 2,4,6-trimethylaniline 
• 302963-97-9 2-tert-butoxycarbonyloxyamino-4-trifluoromethyl-thiazole-5-carboxylic acid 
• 302963-96-8 2-((tert-butoxycarbonyl)amino)-4-(trifluoromethyl)thiazole-5-carboxylic acid ethyl ester 
• 344-72-9 ethyl 2-amino-4-(trifluoromethyl)-5-thiazole-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

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Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56Lck

A novel series of 2-amino-5-carboxamidothiazoles were identified as inhibitors of Lck. Structure-activity studies demonstrate the structural requirements for potent Lck activity. Cyclopropylamide 11d is a potent Lck inhibitor having sub-micromolar activity in a PBL proliferation assay.