303162-37-0

Basic information

• Product Name: Carbamic acid, [4-[2-(3-methylphenyl)-2-oxoethyl]-2-pyridinyl]-, 1,1-dimethylethyl ester
• CAS NO: 303162-37-0
• Molecular Formula: C19H22N2O3
• Molecular Weight: 326.395
• Mol File: 303162-37-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [4-[2-(3-methylphenyl)-2-oxoethyl]-2-pyridinyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [4-[2-(3-methylphenyl)-2-oxoethyl]-2-pyridinyl]-, 1,1-dimethylethyl ester(303162-37-0)
• EPA Substance Registry System: Carbamic acid, [4-[2-(3-methylphenyl)-2-oxoethyl]-2-pyridinyl]-, 1,1-dimethylethyl ester(303162-37-0)

Safety Data

• Hazardous Substances Data: 303162-37-0(Hazardous Substances Data)

Upstream product

• 90101-20-5 tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate 
• 21384-43-0 1-(3-methylbenzoyl)-2-methylaziridine 

Downstream Products

• 303162-40-5 4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}pyridin-2-amine 
• 303162-38-1 4-[2-methyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine 
• 303162-39-2 4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine 
• 896737-68-1 N-{4-[2-(3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}benzamide 
• 896737-61-4 4-[2-(3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-amine 
• 896737-55-6 4-[6-chloro-2-(3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-amine 
• 303162-42-7 2-(2-amino-pyridin-4-yl)-1-(3-methylphenyl)ethanone 
• 303162-78-9 N-(4-{4-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1,3-thiazol-5-yl}-2-pyridyl)-2-phenylacetamide 
• 303163-16-8 N-[4-[4-(3-methylphenyl)-2-(4-methylthiophenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]-N-(2-phenylethyl)amine 
• 303162-93-8 N-[4-[4-(3-methylphenyl)-2-(4-methylthiophenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]benzamide 
• 303163-15-7 N-benzyl-N-[4-[4-(3-methylphenyl)-2-(4-methylthiophenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]amine 
• 303162-80-3 N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]-3-phenylpropionamide 
• 303162-85-8 N-[4-[4-(3-methylphenyl)-2-propyl-1,3-thiazol-5-yl]-pyridin-2-yl]benzamide 
• 303162-74-5 N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]phenylacetamide 

Relevant articles and documents

Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors

We identified novel potent inhibitors of p38 MAP kinase using structure-based design strategy. X-ray crystallography showed that when p38 MAP kinase is complexed with TAK-715 (1) in a co-crystal structure, Phe169 adopts two conformations, where one intera

MEDICINAL COMPOSITIONS

The present invention relates to an agent for the prophylaxis or treatment of pain, an agent for suppressing activation of osteoclast, and an inhibitor of osteoclast formation, which contains a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor.

5-PYRIDYL-1,3-AZOLE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

An optionally N-oxidized compound represented by the formula: wherein R1 represents hydrogen, hydrocarbon, heterocycle, amino, acyl, R2 represents an aromatic group, R3 represents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR4 (R4 represents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine A3 receptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine A3 receptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-α inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-α.