30414-00-7 Usage
Description
5-(Hydroxymethyl)uridine is a naturally occurring modified nucleoside and a derivative of uridine, which is found in various human tissues and fluids. It plays a significant role in RNA modification and biosynthesis, and has potential therapeutic applications in treating mitochondrial disorders and as a neuroprotective agent. It also has potential effects on mitochondrial biogenesis and improving energy metabolism in cells.
Uses
Used in Pharmaceutical Industry:
5-(Hydroxymethyl)uridine is used as a therapeutic agent for the treatment of mitochondrial disorders due to its potential role in improving mitochondrial function and energy metabolism in cells.
Used in Neuroprotection:
5-(Hydroxymethyl)uridine is used as a neuroprotective agent to protect neurons from damage and degeneration, potentially offering benefits in the treatment of neurodegenerative diseases.
Used in Research:
5-(Hydroxymethyl)uridine is used as a research tool to study RNA modification, biosynthesis, and its effects on cellular processes, contributing to a better understanding of its biological significance and potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 30414-00-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,4,1 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 30414-00:
(7*3)+(6*0)+(5*4)+(4*1)+(3*4)+(2*0)+(1*0)=57
57 % 10 = 7
So 30414-00-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O7/c13-2-4-1-12(10(18)11-8(4)17)9-7(16)6(15)5(3-14)19-9/h1,5-7,9,13-16H,2-3H2,(H,11,17,18)/t5-,6-,7-,9-/m1/s1
30414-00-7Relevant articles and documents
SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS
-
, (2019/01/15)
This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.
Alternative synthetic routes to 2′,3′-didehydro-2′,3′-dideoxy-5-hydroxymethyluridine
Chung, Raymond,Anderson, Karen S.
, p. 8361 - 8363 (2007/10/03)
Alternative syntheses for the nucleoside analogue 2′,3′-didehydro-2′,3′-dideoxy-5-hydroxymethyluridine starting from 5-methyluridine and uridine are described.
Synthesis of 5-(2-amino-2-deoxy-β-D-glucopyranosyloxymethyl)-2'- deoxyuridine and its incorporation into oligothymidylates
Hunziker, Juerg
, p. 201 - 204 (2007/10/03)
The protected 5-(2-amino-2-deoxy-β-D-glucopyranosyloxymethyl)-2'- deoxyuridine phosphoramidite 15 has been prepared from uridine in 12 steps. When incorporated into oligodeoxyribonucleotides the novel nucleoside analog 5 leads to decreased binding affinit
