30529-70-5

Basic information

• Product Name: 2-Chloro-6-methylnicotinic acid
• Synonyms: 2-chloro-6-methylpyridine-3-carboxylic acid;2-Chloro-6-methylnicotinic acid 98%;2-CHLORO-6-METHYL-3-PYRIDINECARBOXYLIC ACID 99+%;2-Chloro-6-methyl-3-pyridinecarboxylic acid, 2-Chloro-6-methylnicotinic acid;2-chloro-6-methyl-1,2-dihydropyridine-3-carboxylic acid;4-Chloro-6-methylnicotinic acid;2-Chloro-6-Methylnicotinic acid, 98+%;2-Chloro-6-Methylnicotinic acid, 99+% 5GR
• CAS NO: 30529-70-5
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• EINECS: 250-229-7
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Organic acids;Pyridine series;Chloropyridines;Halopyridines;Pharm intermediate
• Mol File: 30529-70-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 162-164 °C(lit.)
• Boiling Point: 163 °C / 22mmHg
• Flash Point: 150.7 °C
• Appearance: White to yellow to beige/Crystalline Powder
• Density: 1.3246 (rough estimate)
• Vapor Pressure: 9.34E-05mmHg at 25°C
• Refractive Index: 1.5560 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 2.28±0.28(Predicted)
• BRN: 473070
• CAS DataBase Reference: 2-Chloro-6-methylnicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-methylnicotinic acid(30529-70-5)
• EPA Substance Registry System: 2-Chloro-6-methylnicotinic acid(30529-70-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 30529-70-5(Hazardous Substances Data)

Usage

Description

2-Chloro-6-methylnicotinic acid, also known as 2-Chloro-6-methylpyridine-3-carboxylic acid, is a nicotinic acid derivative characterized by its white to yellow crystalline powder form. It is a chemical compound with a unique structure that makes it a valuable intermediate in the synthesis of other organic compounds.

Uses

Used in Chemical Synthesis:
2-Chloro-6-methylnicotinic acid is used as a key intermediate in the synthesis of 6-methyl-2-thiophenoxynicotinic acid, which is an essential component in the preparation of europium complexes.
Used in Cell Biology Research:
In the field of cell biology, 2-Chloro-6-methylnicotinic acid plays a crucial role in the preparation of europium complexes that are used for staining the nucleolus of various cell types, such as NIH 3T3, HeLa, and HDF cells. This staining process aids researchers in studying the structure and function of the nucleolus, which is vital for ribosomal RNA synthesis and cell division.

InChI:InChI=1/C7H6ClNO2/c1-4-2-3-5(7(10)11)6(8)9-4/h2-3H,1H3,(H,10,11)/p-1

Upstream product

• 38116-61-9 2-hydroxy-6-methylnicotinic acid 
• 28900-10-9 2-chloro-6-methylnicotinonitrile 

Downstream Products

• 689146-99-4 2-chloro-N-{4-[4-(3-cyanobenzyl)-1-piperazinyl]phenyl}-6-methylnicotinamide 
• 53277-47-7 2-chloro-6-methylnicotinic acid methyl ester 
• 344352-53-0 6-methyl-2-(3-methylthiophenylamino)nicotinaldehyde 
• 1379464-90-0 2-chloro-N-(2-methoxyphenyl)-6-methylnicotinamide 
• 1379464-92-2 N-(2-methoxyphenyl)-6-methyl-2-((4-nitrophenyl)thio)nicotinamide 
• 39073-14-8 ethyl 2-chloro-6-methyl-3-pyridinecarboxylate 
• 485812-85-9 N-ethyl-6-methyl-3-[3-(trifluoromethyl)benzoyl]pyridin-2-amine 
• 178548-58-8 YM-976 
• 178548-55-5 4-(3-chloro-phenyl)-1-ethyl-7-methyl-1H-[1,8]naphthyridin-2-one 

Relevant articles and documents

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Herbicidal pyridopyridazinones and pyridopyridazinethiones

Pyrido[2,3-d]pyridazin-5-one and pyrido[2,3-d]pyridazin-5-thione derivatives of general formula (I): STR1 wherein R and R1 independently represent hydrogen, optionally halogenated alkyl, alkenyl or alkynyl, optionally substituted heterocycle or a group --[CR41 R42 ]n -(phenyl)-(R3)q ; R2 represents halogen, optionally halogenated alkyl, alkenyl or alkynyl, CN; --CO2 R4 ; --S(O)r R4 ; --NO2 ; --NR41 R42 ; --OH; --COR4, --S(O)r R5, --CO2 R5, --OR5 ; --CONR41 R42, --OSO2 R5, --OSO2 R6, --OCH2 R5, --N(R41)COR6, --N(R41)SO2 R5, --N(R41)SO2 R6, --SO2 NR41 R42, optionally substituted phenyl, alkoxy or haloalkoxy; X represents oxygen or sulphur; R3 represents halogen, optionally halogenated alkyl, alkenyl, alkoxy, alkynyl, --OH, --S(O)r R4, --CO2 R4, COR4, --CN, --NO2, --NR41 R42, --OR5 ; --CONR41 R42, --OSO2 R5, --OSO2 R6, --OCH2 R5, --N(R41)COR6, --N(R41)SO2 R5, --N(R41)SO2 R6 or --SO2 NR41 R42 ; R4 represents a hydrogen atom or optionally halogenated C1-6 alkyl; R41 and R42, which may be the same or different, each represents a hydrogen atom or optionally halogenated C1-4 alkyl; R5 represents a phenyl group optionally substituted by from one to five groups selected from halogen, nitro, cyano, R4 and --OR4 ; m represents zero or an integer from one to three; n represents zero, one or two; where n is two, the groups --(CR41 R42)-- may be the same or different; q represents zero or an integer from one to five; r represents zero, one or two; with the proviso that when m represents zero R and R1 do not simultaneously represent hydrogen; and agriculturally acceptable salts thereof are useful as herbicides.