30532-36-6Relevant articles and documents
Synthesis, SAR and selectivity of 2-acyl- and 2-cyano-1-hetarylalkyl- guanidines at the four histamine receptor subtypes: A bioisosteric approach
Geyer, Roland,Igel, Patrick,Kaske, Melanie,Elz, Sigurd,Buschauer, Armin
, p. 72 - 81 (2014/01/06)
In the search for potential bioisosteres of the 4-imidazolyl ring in acylguanidines (e.g. UR-AK24), known to possess affinity to several histamine receptor subtypes (HxR, x = 1-4), and cyanoguanidine-type H 4R agonists (e.g. UR-PI376
Discovery of thieno[3,2-d ]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3
Disch, Jeremy S.,Evindar, Ghotas,Chiu, Cynthia H.,Blum, Charles A.,Dai, Han,Jin, Lei,Schuman, Eli,Lind, Kenneth E.,Belyanskaya, Svetlana L.,Deng, Jianghe,Coppo, Frank,Aquilani, Leah,Graybill, Todd L.,Cuozzo, John W.,Lavu, Siva,Mao, Cheney,Vlasuk, George P.,Perni, Robert B.
, p. 3666 - 3679 (2013/06/27)
The sirtuins SIRT1, SIRT2, and SIRT3 are NAD+ dependent deacetylases that are considered potential targets for metabolic, inflammatory, oncologic, and neurodegenerative disorders. Encoded library technology (ELT) was used to affinity screen a 1
Syntheses and biological activities of structurally stiff rhodacyanines as novel antimalarial candiadates
Takasu, Kiyosei,Morisaki, Daiki,Kaiser, Marcel,Brun, Reto,Ihara, Masataka
, p. 161 - 166 (2007/10/03)
New classes of rhodacyanine as structurally stiff derivatives were designed and synthesized. The synthetic compounds were evaluated the antimalarial activity and cytotoxicity in vitro.